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Defy Medical vs HealthRX: Which Is Better?

Head-to-head comparison of Defy Medical and HealthRX based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 59.3/100), leading on trust & safety, experience, product range, reputation. HealthRX comes out ahead on value. HealthRX has the lower entry price (from $99/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
59

HealthRX.com is a compounded-GLP-1 telehealth marketplace. It sells semaglutide at $165/mo and tirzepatide at $214/mo at every dose, and backs its program with a weight-loss money-back guarantee.

Visit HealthRX

Score Breakdown

DimensionDefy MedicalHealthRX
Overall Score71.9/100 ✓59.3/100
Trust & Safety30%72/100 ✓55/100
Value25%60/10078/100 ✓
Experience20%78/100 ✓60/100
Product Range15%78/100 ✓45/100
Reputation10%80/100 ✓45/100

At a Glance

Founded20112023
HeadquartersTampa, FL—
Publicly tradedNoNo
Treatment categories31
Treatments listed42
Starting price$150/mo$99/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalHealthRX
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$99–$165
Compounded Semaglutide

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

HealthRX

+Flat pricing at every dose: semaglutide $165/mo ($149 first month) and tirzepatide $214/mo ($193 first month); about $99/mo semaglutide on a 12-month plan
+Physician review within 24 hours, overnight cold-chain shipping included, and a full refund if not prescribed
+Weight-loss money-back guarantee (reported terms: 16+ weeks on treatment, 10% loss threshold)
−Operating company, headquarters, medical group and dispensing pharmacy are not named; terms reference only a San Diego dispute venue
−Guarantee measurement and refund mechanics are not fully published
−Thin independent review footprint for a brand active since about 2023
Read the full HealthRX review →

Defy Medical vs HealthRX — FAQ

Is Defy Medical better than HealthRX?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 59.3/100), leading on trust & safety, experience, product range, reputation. HealthRX comes out ahead on value. HealthRX has the lower entry price (from $99/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or HealthRX cheaper?

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HealthRX has the lower starting price (from $99/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and HealthRX both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and HealthRX covers 1.

Still deciding?

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