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Defy Medical vs HumeCare+: Which Is Better?

Head-to-head comparison of Defy Medical and HumeCare+ based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 54.2/100), leading on trust & safety, experience, product range, reputation.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
54
HumeCare+
Below Average

HumeCare+ is the GLP-1 weight-loss program from smart-scale maker Hume Health. It bundles clinician-prescribed GLP-1 medication with a Hume Pod body-composition scale and app tracking, starting at $199/mo.

Visit HumeCare+

Score Breakdown

DimensionDefy MedicalHumeCare+
Overall Score71.9/100 ✓54.2/100
Trust & Safety30%72/100 ✓52/100
Value25%60/10060/100
Experience20%78/100 ✓58/100
Product Range15%78/100 ✓50/100
Reputation10%80/100 ✓45/100

At a Glance

Founded2011—
HeadquartersTampa, FLWilmington, DE
Publicly tradedNoNo
Treatment categories31
Treatments listed42
Starting price$150/mo$199/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalHumeCare+
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$199
HumeCare+ Compounded Semaglutide Protocol

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

HumeCare+

+Includes a Hume Pod body-composition scale (listed at $352) and monthly scans, so patients can track fat versus lean-mass change during GLP-1 treatment
+Protocol adds glycine, B12 and B6 aimed at muscle preservation and tolerability
+Advertises a refund if the patient does not lose 10% of body weight within 6 months (terms apply); FSA/HSA eligible
−Parent Hume Health holds a BBB F rating with 348 complaints closed in three years and a 3.5/5 Trustpilot score, mostly about refunds, device accuracy and support
−The prescribing medical group, the dispensing pharmacy and the state list are not published, and full pricing only appears after intake
−3-month minimum commitment; $199/mo headline requires a $100 welcome credit
Read the full HumeCare+ review →

Defy Medical vs HumeCare+ — FAQ

Is Defy Medical better than HumeCare+?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 54.2/100), leading on trust & safety, experience, product range, reputation.

Is Defy Medical or HumeCare+ cheaper?

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Defy Medical has the lower starting price (from $150/mo vs $199/mo for HumeCare+). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and HumeCare+ both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and HumeCare+ covers 1.

Still deciding?

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