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Defy Medical vs MangoRx: Which Is Better?

Head-to-head comparison of Defy Medical and MangoRx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 58/100), leading on trust & safety, experience, product range, reputation. MangoRx comes out ahead on value. MangoRx has the lower entry price (from $50/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
58

MangoRx is the Dallas-based men's health telehealth brand of Nasdaq-listed Mangoceuticals, selling compounded ED, hair-loss and oral semaglutide products alongside injectable and oral (Kyzatrex) testosterone.

Visit MangoRx

Score Breakdown

DimensionDefy MedicalMangoRx
Overall Score71.9/100 ✓58/100
Trust & Safety30%72/100 ✓55/100
Value25%60/10062/100 ✓
Experience20%78/100 ✓58/100
Product Range15%78/100 ✓66/100
Reputation10%80/100 ✓45/100

At a Glance

Founded20112021
HeadquartersTampa, FLDallas, TX
Publicly tradedNoYes (MGRX)
Treatment categories35
Treatments listed45
Starting price$150/mo$50/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalMangoRx
Hormone Therapy$150–$250
Women's Bioidentical HRT
$99
Injectable TRT (testosterone cypionate)
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$299
Slim (compounded oral semaglutide ODT)
Sexual Health—$59–$75
Mango ED (sildenafil or tadalafil)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

MangoRx

+Injectable TRT program priced at $99/month with doctor visits, lab work and medication included (per February 2026 company release and current site listing)
+Offers a branded FDA-approved oral testosterone option (Kyzatrex-based 'Prime') alongside compounded injectable TRT, which few small men's-health platforms carry
+Public-company SEC disclosures make ownership, pharmacy relationships and finances unusually visible for a brand this size
−Going-concern risk: $228,688 cash on hand at June 30, 2026 against a six-month net loss of $4.7M, per its Q2 2026 10-Q
−Compounded products are filled by Epiq Scripts, a pharmacy majority-owned (52%) by the CEO, a related-party arrangement
−Very small patient base: Q2 2026 revenue of $68,757, down 59% year over year, and only 18 Trustpilot reviews
Read the full MangoRx review →

Defy Medical vs MangoRx — FAQ

Is Defy Medical better than MangoRx?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 58/100), leading on trust & safety, experience, product range, reputation. MangoRx comes out ahead on value. MangoRx has the lower entry price (from $50/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or MangoRx cheaper?

▾

MangoRx has the lower starting price (from $50/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and MangoRx both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and MangoRx covers 5.

Still deciding?

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