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Defy Medical vs Paloma Health: Which Is Better?

Head-to-head comparison of Defy Medical and Paloma Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 57.7/100), leading on trust & safety, experience, product range, reputation. Paloma Health comes out ahead on value. Paloma Health has the lower entry price (from $20/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
58

A niche telehealth brand built specifically around hypothyroidism and Hashimoto's care, pairing at-home lab testing with endocrinology-informed treatment.

Visit Paloma Health

Score Breakdown

DimensionDefy MedicalPaloma Health
Overall Score71.9/100 ✓57.7/100
Trust & Safety30%72/100 ✓58/100
Value25%60/10062/100 ✓
Experience20%78/100 ✓55/100
Product Range15%78/100 ✓55/100
Reputation10%80/100 ✓55/100

At a Glance

Founded20112018
HeadquartersTampa, FLNew York, NY
Publicly tradedNoNo
Treatment categories32
Treatments listed43
Starting price$150/mo$20/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalPaloma Health
Hormone Therapy$150–$250
Women's Bioidentical HRT
$20
Thyroid Care Membership

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Paloma Health

+Narrow clinical focus on hypothyroidism/Hashimoto's with endocrinologist-informed care teams and integrated at-home lab testing, nutritionist visits, and medication management in one program.
+Transparent flat membership pricing ($20/mo billed $240/yr) that bundles two test kits and two visits per year.
+One of the only brands to specialize specifically in DTC thyroid care rather than treating it as one line item among many.
−Trustpilot rating is weak (2.6/5, though based on a very small sample of 4 reviews) with recurring complaints of care that didn't match advertised 'integrative'/'holistic' positioning.
−At least one reported case of a patient with clearly abnormal labs (TSH of 58) alleging the prescribing clinician disregarded their reported symptoms before prescribing a medication that caused adverse reactions — a serious quality-of-care concern for a specialty-clinical brand.
−Reviewers report membership fees and per-visit charges stacking in ways that felt like hidden costs.
Read the full Paloma Health review →

Defy Medical vs Paloma Health — FAQ

Is Defy Medical better than Paloma Health?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 57.7/100), leading on trust & safety, experience, product range, reputation. Paloma Health comes out ahead on value. Paloma Health has the lower entry price (from $20/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or Paloma Health cheaper?

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Paloma Health has the lower starting price (from $20/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Paloma Health both offer?

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Both platforms treat Hormone Therapy. Defy Medical covers 3 treatment categories total and Paloma Health covers 2.

Still deciding?

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