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Defy Medical vs RxSpan MD: Which Is Better?

Head-to-head comparison of Defy Medical and RxSpan MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD has the lower entry price (from $30/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
59

RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

Visit RxSpan MD

Score Breakdown

DimensionDefy MedicalRxSpan MD
Overall Score71.9/100 ✓59.1/100
Trust & Safety30%72/100 ✓60/100
Value25%60/100 ✓58/100
Experience20%78/100 ✓52/100
Product Range15%78/10078/100
Reputation10%80/100 ✓45/100

At a Glance

Founded20112026
HeadquartersTampa, FLBeverly Hills, CA
Publicly tradedNoNo
Treatment categories34
Treatments listed49
Starting price$150/mo$30/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalRxSpan MD
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$249–$299
Compounded Semaglutide (injection or oral)
Sexual Health—$30–$100
ED (tadalafil, sildenafil/pycnogenol, vardenafil)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

Defy Medical vs RxSpan MD — FAQ

Is Defy Medical better than RxSpan MD?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD has the lower entry price (from $30/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or RxSpan MD cheaper?

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RxSpan MD has the lower starting price (from $30/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and RxSpan MD both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and RxSpan MD covers 4.

Still deciding?

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