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Defy Medical vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Defy Medical and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 71.9/100), leading on trust & safety, value. Defy Medical comes out ahead on experience, product range, reputation.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionDefy MedicalTwentyeight Health
Overall Score71.9/10075/100 ✓
Trust & Safety30%72/10076/100 ✓
Value25%60/10080/100 ✓
Experience20%78/100 ✓72/100
Product Range15%78/100 ✓72/100
Reputation10%80/100 ✓70/100

At a Glance

Founded20112018
HeadquartersTampa, FLBrooklyn, NY
Publicly tradedNoNo
Treatment categories34
Treatments listed47
Starting price$150/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalTwentyeight Health
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
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Sexual Health——

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Defy Medical vs Twentyeight Health — FAQ

Is Defy Medical better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 71.9/100), leading on trust & safety, value. Defy Medical comes out ahead on experience, product range, reputation.

Is Defy Medical or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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