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Defy Medical vs Wellmedr: Which Is Better?

Head-to-head comparison of Defy Medical and Wellmedr based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 60.8/100), leading on trust & safety, experience, product range, reputation. Wellmedr comes out ahead on value. Wellmedr has the lower entry price (from $40/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
61

Wellmedr is a St. Petersburg, FL telehealth brand launched in 2025. It sells low-priced compounded semaglutide and tirzepatide plus ED, enclomiphene, hair-loss and NAD+ treatments, prescribed through OpenLoop Health.

Visit Wellmedr

Score Breakdown

DimensionDefy MedicalWellmedr
Overall Score71.9/100 ✓60.8/100
Trust & Safety30%72/100 ✓50/100
Value25%60/10078/100 ✓
Experience20%78/100 ✓55/100
Product Range15%78/100 ✓72/100
Reputation10%80/100 ✓45/100

At a Glance

Founded20112025
HeadquartersTampa, FLSt. Petersburg, FL
Publicly tradedNoNo
Treatment categories36
Treatments listed46
Starting price$150/mo$40/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalWellmedr
Hormone Therapy$150–$250
Women's Bioidentical HRT
$80–$150
Enclomiphene + Anastrozole
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$49–$149
Compounded Semaglutide (+NAD+/B12)
Sexual Health—$60–$120
Black Pill 3-in-1 (sildenafil/tadalafil/apomorphine)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Wellmedr

+Some of the lowest compounded GLP-1 prices we track: $49/mo semaglutide and $89/mo tirzepatide on 12-month plans, the same at every dose
+Broad catalog for a new brand, spanning GLP-1s, a 3-in-1 ED pill, enclomiphene, a 4-in-1 hair-loss formula and NAD+
+Unlimited clinician messaging and 1–4 hour approval target; 90-day money-back guarantee advertised
−BBB rating of F with 75 complaints since its May 2025 start; BBB flagged a pattern of late or temperature-mishandled deliveries, charges after cancellation and refused guarantee refunds
−Reviewers report billing every 21 days rather than monthly, which adds charges over a year
−Dispensing pharmacies are not named, and prescribing is outsourced to OpenLoop Health and 'other networks'
Read the full Wellmedr review →

Defy Medical vs Wellmedr — FAQ

Is Defy Medical better than Wellmedr?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 60.8/100), leading on trust & safety, experience, product range, reputation. Wellmedr comes out ahead on value. Wellmedr has the lower entry price (from $40/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or Wellmedr cheaper?

▾

Wellmedr has the lower starting price (from $40/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Wellmedr both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and Wellmedr covers 6.

Still deciding?

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