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Defy Medical vs Yucca Health: Which Is Better?

Head-to-head comparison of Defy Medical and Yucca Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 68.3/100), leading on trust & safety, experience, product range, reputation. Yucca Health comes out ahead on value. Yucca Health has the lower entry price (from $125/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
68

Yucca Health is a Beverly Hills-based telehealth platform selling compounded semaglutide and tirzepatide at flat, dose-independent prices, plus compounded NAD+ and sermorelin.

Visit Yucca Health

Score Breakdown

DimensionDefy MedicalYucca Health
Overall Score71.9/100 ✓68.3/100
Trust & Safety30%72/100 ✓64/100
Value25%60/10080/100 ✓
Experience20%78/100 ✓72/100
Product Range15%78/100 ✓58/100
Reputation10%80/100 ✓60/100

At a Glance

Founded20112025
HeadquartersTampa, FLBeverly Hills, CA
Publicly tradedNoNo
Treatment categories32
Treatments listed44
Starting price$150/mo$125/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalYucca Health
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$125–$146
Compounded Semaglutide+ (injectable)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Yucca Health

+Full price grid published before intake: semaglutide $146/mo monthly, $140/mo quarterly or $125/mo on a 6-month prepay; tirzepatide $258, $248 or $225/mo
+Locked pricing covers the whole dose range, so titrating up does not raise the bill; pausing keeps the locked rate
+No separate membership or consultation fee; plans include the provider consult, medication, injection supplies and free 2-day shipping
−Dispensing pharmacies are not named on the public site; they appear only in the patient portal and on the label after ordering
−BBB rating of C+ (not accredited) with five closed complaints; one Trustpilot reviewer reports prepaying six months and receiving three
−About 6% of roughly 1,230 Trustpilot reviews are 1-star, citing lack of results after months of treatment and refund disputes
Read the full Yucca Health review →

Defy Medical vs Yucca Health — FAQ

Is Defy Medical better than Yucca Health?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 68.3/100), leading on trust & safety, experience, product range, reputation. Yucca Health comes out ahead on value. Yucca Health has the lower entry price (from $125/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or Yucca Health cheaper?

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Yucca Health has the lower starting price (from $125/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Yucca Health both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and Yucca Health covers 2.

Still deciding?

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