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Effecty vs Synergy Rx: Which Is Better?

Head-to-head comparison of Effecty and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Effecty scores higher overall in our independent evaluation (66.8/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

67

New York-based cash-pay telehealth brand selling compounded GLP-1s, longevity injectables (NAD+, sermorelin, glutathione) and estradiol HRT with no membership fee and published tiered pricing.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionEffectySynergy Rx
Overall Score66.8/100 ✓51.9/100
Trust & Safety30%60/100 ✓48/100
Value25%76/100 ✓60/100
Experience20%72/100 ✓50/100
Product Range15%66/100 ✓58/100
Reputation10%55/100 ✓38/100

At a Glance

Founded20242026
HeadquartersNew York, NY—
Publicly tradedNoNo
Treatment categories43
Treatments listed99
Starting price$55/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEffectySynergy Rx
Weight Loss / GLP-1$80
Metformin
$199
Compounded Semaglutide (injectable)
Longevity & Peptides$95–$150
Lipotropic (MIC) + B12
$109
B12 Methylcobalamin

Effecty

+No membership fee, and prices are published per product and don't change with dose (semaglutide $130–$170/mo, tirzepatide $190–$235/mo)
+Card is held, not charged, until a prescription is written; shipping is free and expedited
+4.6/5 on Trustpilot across ~1,300 reviews, most citing fast support responses
−Only operating since November 2024; BBB rating is B with three closed complaints
−Visits are chat-only, and the compounding pharmacies are not named on the site
−Lowest advertised prices require 12-month prepayment; month-to-month runs 25–30% higher
Read the full Effecty review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Effecty vs Synergy Rx — FAQ

Is Effecty better than Synergy Rx?

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Effecty scores higher overall in our independent evaluation (66.8/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is Effecty or Synergy Rx cheaper?

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Effecty has the lower starting price (from $55/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Effecty and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Effecty covers 4 treatment categories total and Synergy Rx covers 3.

Still deciding?

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