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Enhance.MD vs He & She MD: Which Is Better?

Head-to-head comparison of Enhance.MD and He & She MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 65.3/100), leading on trust & safety, experience, reputation. He & She MD comes out ahead on value, product range. He & She MD has the lower entry price (from $60/mo vs $169/mo), so the better value depends on which treatment you need.

Enhance.MD

Good

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

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He & She MD

Good

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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Score Breakdown

Dimension	Enhance.MD	He & She MD
Overall Score	66.9/100 ✓	65.3/100
Trust & Safety30%	76/100 ✓	58/100
Value25%	60/100	74/100 ✓
Experience20%	68/100 ✓	60/100
Product Range15%	60/100	84/100 ✓
Reputation10%	65/100 ✓	48/100

At a Glance

Founded	2019	2025
Headquarters	San Diego, CA	Newport Beach, CA
Publicly traded	No	No
Treatment categories	2	7
Treatments listed	5	13
Starting price	$169/mo	$60/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Enhance.MD	He & She MD
Weight Loss / GLP-1	$169 Microdose Tirzepatide	$99–$199 Compounded Semaglutide (injectable)
Longevity & Peptides	$169 NAD+ Therapy	$100–$149 Glutathione

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price

+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)

+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible

−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests

−Not available in 10 states, including GA, TN and MO

−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches

Read the full Enhance.MD review →

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED

+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds

+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose

−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified

−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299

−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices

Read the full He & She MD review →

Enhance.MD vs He & She MD — FAQ

Is Enhance.MD better than He & She MD?

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Is Enhance.MD or He & She MD cheaper?

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He & She MD has the lower starting price (from $60/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and He & She MD both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Enhance.MD covers 2 treatment categories total and He & She MD covers 7.

Still deciding?

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