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Enhance.MD vs PlushCare: Which Is Better?

Head-to-head comparison of Enhance.MD and PlushCare based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

PlushCare scores higher overall in our independent evaluation (68.3/100 vs 66.9/100), leading on trust & safety, value, product range, reputation. Enhance.MD comes out ahead on experience.

67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD
68

PlushCare is a virtual primary-care membership service that layers weight-loss visits and branded GLP-1 prescriptions onto its core telehealth offering, rather than running a dedicated compounded-GLP-1 program.

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Score Breakdown

DimensionEnhance.MDPlushCare
Overall Score66.9/10068.3/100 ✓
Trust & Safety30%76/10078/100 ✓
Value25%60/10062/100 ✓
Experience20%68/100 ✓62/100
Product Range15%60/10065/100 ✓
Reputation10%65/10072/100 ✓

At a Glance

Founded20192014
HeadquartersSan Diego, CASan Francisco, CA
Publicly tradedNoNo
Treatment categories22
Treatments listed53
Starting price$169/mo$20/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDPlushCare
Weight Loss / GLP-1$169
Microdose Tirzepatide
$650–$1100
Branded GLP-1 Prescription (Wegovy, Saxenda)

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

PlushCare

+Low $19.99/mo membership with first month free, and insurance-eligible visits as low as a $30 copay
+Accepts major insurance plans (Aetna, Cigna, Humana), broader than most single-purpose GLP-1 telehealth startups
+Physician-led primary care model covers ongoing and chronic care beyond a single weight-loss funnel
−Branded GLP-1 medication (Zepbound, Wegovy) is billed separately at the pharmacy — without insurance coverage this can run roughly $1,000+/month, dwarfing the low membership fee
−No compounded GLP-1 option, so cash-pay patients without drug coverage face full retail brand pricing
−Trustpilot pattern of unexpected recurring membership charges and difficulty cancelling
Read the full PlushCare review →

Enhance.MD vs PlushCare — FAQ

Is Enhance.MD better than PlushCare?

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PlushCare scores higher overall in our independent evaluation (68.3/100 vs 66.9/100), leading on trust & safety, value, product range, reputation. Enhance.MD comes out ahead on experience.

Is Enhance.MD or PlushCare cheaper?

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PlushCare has the lower starting price (from $20/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and PlushCare both offer?

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Both platforms treat Weight Loss / GLP-1. Enhance.MD covers 2 treatment categories total and PlushCare covers 2.

Still deciding?

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