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Enhance.MD vs ProlongMD: Which Is Better?

Head-to-head comparison of Enhance.MD and ProlongMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 60.1/100), leading on trust & safety, experience, reputation. ProlongMD comes out ahead on value, product range. ProlongMD has the lower entry price (from $25/mo vs $169/mo), so the better value depends on which treatment you need.

Enhance.MD

Good

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD

ProlongMD

Fair

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD

Score Breakdown

Dimension	Enhance.MD	ProlongMD
Overall Score	66.9/100 ✓	60.1/100
Trust & Safety30%	76/100 ✓	52/100
Value25%	60/100	74/100 ✓
Experience20%	68/100 ✓	55/100
Product Range15%	60/100	70/100 ✓
Reputation10%	65/100 ✓	45/100

At a Glance

Founded	2019	2025
Headquarters	San Diego, CA	Phoenix, AZ
Publicly traded	No	No
Treatment categories	2	8
Treatments listed	5	13
Starting price	$169/mo	$25/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Enhance.MD	ProlongMD
Weight Loss / GLP-1	$169 Microdose Tirzepatide	$99–$119 Compounded Semaglutide/B12
Longevity & Peptides	$169 NAD+ Therapy	$179 Sermorelin

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price

+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)

+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible

−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests

−Not available in 10 states, including GA, TN and MO

−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches

Read the full Enhance.MD review →

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee

+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs

+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits

−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form

−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)

−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text

Read the full ProlongMD review →

Enhance.MD vs ProlongMD — FAQ

Is Enhance.MD better than ProlongMD?

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Is Enhance.MD or ProlongMD cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and ProlongMD both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Enhance.MD covers 2 treatment categories total and ProlongMD covers 8.

Still deciding?

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