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Enhance.MD vs RxSpan MD: Which Is Better?

Head-to-head comparison of Enhance.MD and RxSpan MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range. RxSpan MD has the lower entry price (from $30/mo vs $169/mo), so the better value depends on which treatment you need.

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Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD
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RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

Visit RxSpan MD

Score Breakdown

DimensionEnhance.MDRxSpan MD
Overall Score66.9/100 ✓59.1/100
Trust & Safety30%76/100 ✓60/100
Value25%60/100 ✓58/100
Experience20%68/100 ✓52/100
Product Range15%60/10078/100 ✓
Reputation10%65/100 ✓45/100

At a Glance

Founded20192026
HeadquartersSan Diego, CABeverly Hills, CA
Publicly tradedNoNo
Treatment categories24
Treatments listed59
Starting price$169/mo$30/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDRxSpan MD
Weight Loss / GLP-1$169
Microdose Tirzepatide
$249–$299
Compounded Semaglutide (injection or oral)
Longevity & Peptides$169
NAD+ Therapy
$100–$200
Glutathione

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

Enhance.MD vs RxSpan MD — FAQ

Is Enhance.MD better than RxSpan MD?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range. RxSpan MD has the lower entry price (from $30/mo vs $169/mo), so the better value depends on which treatment you need.

Is Enhance.MD or RxSpan MD cheaper?

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RxSpan MD has the lower starting price (from $30/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and RxSpan MD both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Enhance.MD covers 2 treatment categories total and RxSpan MD covers 4.

Still deciding?

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