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Enhance.MD vs Sermorelin.com: Which Is Better?

Head-to-head comparison of Enhance.MD and Sermorelin.com based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 58/100), leading on trust & safety, experience, product range, reputation. Sermorelin.com comes out ahead on value. Sermorelin.com has the lower entry price (from $149/mo vs $169/mo), so the better value depends on which treatment you need.

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD

Single-product telehealth brand that sells compounded sermorelin as a nightly injection or an under-the-tongue tablet, prescribed by a Florida-based medical group.

Visit Sermorelin.com

Score Breakdown

DimensionEnhance.MDSermorelin.com
Overall Score66.9/100 ✓58/100
Trust & Safety30%76/100 ✓60/100
Value25%60/10068/100 ✓
Experience20%68/100 ✓62/100
Product Range15%60/100 ✓36/100
Reputation10%65/100 ✓52/100

At a Glance

Founded2019—
HeadquartersSan Diego, CASheridan, WY
Publicly tradedNoNo
Treatment categories21
Treatments listed52
Starting price$169/mo$149/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDSermorelin.com
Longevity & Peptides$169
NAD+ Therapy
$149–$199
Compounded Sermorelin Injection

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Sermorelin.com

+All-in pricing shown before intake ($149-$199/mo) covers the physician consult, medication, supplies and free 2-day shipping
+Names its medical group (Wasef Health, PC, Michael Wasef MD) and dispensing pharmacy (SmartScripts / PerfectRx, Flower Mound, TX) on the site
+Offers injectable and sublingual tablet sermorelin at the same price, and says card holds are only charged after physician approval
−Only one drug is offered, so there are no labs, hormone therapy or other longevity treatments
−Operator is an anonymous Wyoming LLC at a registered-agent address; no named founders or clinical leadership beyond the contracted PC
−On-site testimonials name competitors (MaleMD, Eden) in a promotional way that cannot be independently verified
Read the full Sermorelin.com review →

Enhance.MD vs Sermorelin.com — FAQ

Is Enhance.MD better than Sermorelin.com?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 58/100), leading on trust & safety, experience, product range, reputation. Sermorelin.com comes out ahead on value. Sermorelin.com has the lower entry price (from $149/mo vs $169/mo), so the better value depends on which treatment you need.

Is Enhance.MD or Sermorelin.com cheaper?

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Sermorelin.com has the lower starting price (from $149/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Sermorelin.com both offer?

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Both platforms treat Longevity & Peptides. Enhance.MD covers 2 treatment categories total and Sermorelin.com covers 1.

Still deciding?