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Enhance.MD vs Sesame Care: Which Is Better?

Head-to-head comparison of Enhance.MD and Sesame Care based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Sesame Care scores higher overall in our independent evaluation (74/100 vs 66.9/100), leading on value, experience, product range, reputation. Enhance.MD comes out ahead on trust & safety.

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Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD
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Pay-per-visit marketplace connecting patients with licensed providers — no subscriptions, transparent per-visit pricing.

Visit Sesame Care

Score Breakdown

DimensionEnhance.MDSesame Care
Overall Score66.9/10074/100 ✓
Trust & Safety30%76/100 ✓75/100
Value25%60/10080/100 ✓
Experience20%68/10070/100 ✓
Product Range15%60/10070/100 ✓
Reputation10%65/10070/100 ✓

At a Glance

Founded20192019
HeadquartersSan Diego, CANew York, NY
Publicly tradedNoNo
Treatment categories26
Treatments listed57
Starting price$169/mo$11/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDSesame Care
Weight Loss / GLP-1$169
Microdose Tirzepatide
$59–$99
Weight Loss Program (subscription)

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Sesame Care

+No subscription required — pay-per-visit model
+Transparent pricing shown before booking
+Wide range of specialties available
−No integrated pharmacy
−Less continuity of care than subscriptions
−Provider quality varies in marketplace model
Read the full Sesame Care review →

Enhance.MD vs Sesame Care — FAQ

Is Enhance.MD better than Sesame Care?

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Sesame Care scores higher overall in our independent evaluation (74/100 vs 66.9/100), leading on value, experience, product range, reputation. Enhance.MD comes out ahead on trust & safety.

Is Enhance.MD or Sesame Care cheaper?

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Sesame Care has the lower starting price (from $11/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Sesame Care both offer?

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Both platforms treat Weight Loss / GLP-1. Enhance.MD covers 2 treatment categories total and Sesame Care covers 6.

Still deciding?

Enhance.MD alternativesSesame Care alternativesTake the Match Quiz