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Enhance.MD vs SkinnyRx: Which Is Better?

Head-to-head comparison of Enhance.MD and SkinnyRx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 57.9/100), leading on trust & safety, product range, reputation. SkinnyRx comes out ahead on value, experience.

67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD
58

Cash-pay compounded GLP-1 provider offering five dosing formats, currently facing an FDA warning letter against its parent company.

Visit SkinnyRx

Score Breakdown

DimensionEnhance.MDSkinnyRx
Overall Score66.9/100 ✓57.9/100
Trust & Safety30%76/100 ✓45/100
Value25%60/10068/100 ✓
Experience20%68/10078/100 ✓
Product Range15%60/100 ✓55/100
Reputation10%65/100 ✓35/100

At a Glance

Founded2019—
HeadquartersSan Diego, CA—
Publicly tradedNoNo
Treatment categories21
Treatments listed54
Starting price$169/mo$199/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDSkinnyRx
Weight Loss / GLP-1$169
Microdose Tirzepatide
$199
Semaglutide Injection

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

SkinnyRx

+Five dosing formats (injection, sublingual, tablet) for semaglutide/tirzepatide give patients flexibility
+Large Trustpilot volume (5,390 reviews) at a 4.8 average suggests broad satisfaction
+Reps cited by name in reviews for responsive onboarding guidance
−FDA warning letter reportedly issued to parent company Lean Rx, Inc. (February 2026) — unverified independently this cycle, needs manual confirmation
−Some patients report oral/sublingual formats were ineffective with no visible results
−A reviewer described being required to pay upfront for medication that had no effect
Read the full SkinnyRx review →

Enhance.MD vs SkinnyRx — FAQ

Is Enhance.MD better than SkinnyRx?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 57.9/100), leading on trust & safety, product range, reputation. SkinnyRx comes out ahead on value, experience.

Is Enhance.MD or SkinnyRx cheaper?

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Enhance.MD has the lower starting price (from $169/mo vs $199/mo for SkinnyRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and SkinnyRx both offer?

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Both platforms treat Weight Loss / GLP-1. Enhance.MD covers 2 treatment categories total and SkinnyRx covers 1.

Still deciding?

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