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Enhance.MD vs TrimRx: Which Is Better?

Head-to-head comparison of Enhance.MD and TrimRx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 52/100), leading on trust & safety, experience, product range, reputation. TrimRx comes out ahead on value.

67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

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52
TrimRx
Below Average

San Diego-based GLP-1 weight loss telehealth offering compounded semaglutide and tirzepatide at $179-349/month.

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Score Breakdown

DimensionEnhance.MDTrimRx
Overall Score66.9/100 ✓52/100
Trust & Safety30%76/100 ✓55/100
Value25%60/10070/100 ✓
Experience20%68/100 ✓45/100
Product Range15%60/100 ✓30/100
Reputation10%65/100 ✓45/100

At a Glance

Founded20192024
HeadquartersSan Diego, CASan Diego, CA
Publicly tradedNoNo
Treatment categories21
Treatments listed58
Starting price$169/mo$179/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDTrimRx
Weight Loss / GLP-1$169
Microdose Tirzepatide
$179–$329
Compounded Semaglutide (Oral/Sublingual)

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

TrimRx

+70-85% savings vs brand-name GLP-1s: semaglutide at $199/mo vs $1,000+ retail
+Not included in FDA's 2025 warning letter wave — clean regulatory record
+Multiple delivery formats: injectable, oral tablet, and sublingual drops
−Branded pages advertise 'In Stock' with a price while the same page states TrimRx does not sell, dispense or ship branded medication and the patient pays a pharmacy directly
−Cancellation difficulties: long phone waits, reports of being hung up on; dedicated JoinChargeback page exists
−Strict no-refund policy once medical intake is submitted, even before medication ships
Read the full TrimRx review →

Enhance.MD vs TrimRx — FAQ

Is Enhance.MD better than TrimRx?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 52/100), leading on trust & safety, experience, product range, reputation. TrimRx comes out ahead on value.

Is Enhance.MD or TrimRx cheaper?

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Enhance.MD has the lower starting price (from $169/mo vs $179/mo for TrimRx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and TrimRx both offer?

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Both platforms treat Weight Loss / GLP-1. Enhance.MD covers 2 treatment categories total and TrimRx covers 1.

Still deciding?

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