Home›Compare›Enhance.MD vs Twentyeight Health

Enhance.MD vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Enhance.MD and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66.9/100), leading on value, experience, product range, reputation.

67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionEnhance.MDTwentyeight Health
Overall Score66.9/10075/100 ✓
Trust & Safety30%76/10076/100
Value25%60/10080/100 ✓
Experience20%68/10072/100 ✓
Product Range15%60/10072/100 ✓
Reputation10%65/10070/100 ✓

At a Glance

Founded20192018
HeadquartersSan Diego, CABrooklyn, NY
Publicly tradedNoNo
Treatment categories24
Treatments listed57
Starting price$169/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDTwentyeight Health
Weight Loss / GLP-1$169
Microdose Tirzepatide
—

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Enhance.MD vs Twentyeight Health — FAQ

Is Enhance.MD better than Twentyeight Health?

▾

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 66.9/100), leading on value, experience, product range, reputation.

Is Enhance.MD or Twentyeight Health cheaper?

▾

Twentyeight Health has the lower starting price (from $15/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Twentyeight Health both offer?

▾

Both platforms treat Weight Loss / GLP-1. Enhance.MD covers 2 treatment categories total and Twentyeight Health covers 4.

Still deciding?

Enhance.MD alternativesTwentyeight Health alternativesTake the Match Quiz