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Enhance.MD vs Wellmedr: Which Is Better?

Head-to-head comparison of Enhance.MD and Wellmedr based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 60.8/100), leading on trust & safety, experience, reputation. Wellmedr comes out ahead on value, product range. Wellmedr has the lower entry price (from $40/mo vs $169/mo), so the better value depends on which treatment you need.

Enhance.MD

Good

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD

Wellmedr

Fair

Wellmedr is a St. Petersburg, FL telehealth brand launched in 2025. It sells low-priced compounded semaglutide and tirzepatide plus ED, enclomiphene, hair-loss and NAD+ treatments, prescribed through OpenLoop Health.

Visit Wellmedr

Score Breakdown

Dimension	Enhance.MD	Wellmedr
Overall Score	66.9/100 ✓	60.8/100
Trust & Safety30%	76/100 ✓	50/100
Value25%	60/100	78/100 ✓
Experience20%	68/100 ✓	55/100
Product Range15%	60/100	72/100 ✓
Reputation10%	65/100 ✓	45/100

At a Glance

Founded	2019	2025
Headquarters	San Diego, CA	St. Petersburg, FL
Publicly traded	No	No
Treatment categories	2	6
Treatments listed	5	6
Starting price	$169/mo	$40/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Enhance.MD	Wellmedr
Weight Loss / GLP-1	$169 Microdose Tirzepatide	$49–$149 Compounded Semaglutide (+NAD+/B12)
Longevity & Peptides	$169 NAD+ Therapy	$120–$200 NAD+

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price

+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)

+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible

−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests

−Not available in 10 states, including GA, TN and MO

−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches

Read the full Enhance.MD review →

Wellmedr

+Some of the lowest compounded GLP-1 prices we track: $49/mo semaglutide and $89/mo tirzepatide on 12-month plans, the same at every dose

+Broad catalog for a new brand, spanning GLP-1s, a 3-in-1 ED pill, enclomiphene, a 4-in-1 hair-loss formula and NAD+

+Unlimited clinician messaging and 1–4 hour approval target; 90-day money-back guarantee advertised

−BBB rating of F with 75 complaints since its May 2025 start; BBB flagged a pattern of late or temperature-mishandled deliveries, charges after cancellation and refused guarantee refunds

−Reviewers report billing every 21 days rather than monthly, which adds charges over a year

−Dispensing pharmacies are not named, and prescribing is outsourced to OpenLoop Health and 'other networks'

Read the full Wellmedr review →

Enhance.MD vs Wellmedr — FAQ

Is Enhance.MD better than Wellmedr?

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Is Enhance.MD or Wellmedr cheaper?

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Wellmedr has the lower starting price (from $40/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Wellmedr both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Enhance.MD covers 2 treatment categories total and Wellmedr covers 6.

Still deciding?

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