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He & She MD vs Niagen Plus: Which Is Better?

Head-to-head comparison of He & She MD and Niagen Plus based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

He & She MD scores higher overall in our independent evaluation (65.3/100 vs 64.7/100), leading on value, experience, product range. Niagen Plus comes out ahead on trust & safety, reputation.

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He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

Visit He & She MD
65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus

Score Breakdown

DimensionHe & She MDNiagen Plus
Overall Score65.3/100 ✓64.7/100
Trust & Safety30%58/10078/100 ✓
Value25%74/100 ✓70/100
Experience20%60/100 ✓58/100
Product Range15%84/100 ✓36/100
Reputation10%48/10068/100 ✓

At a Glance

Founded20252024
HeadquartersNewport Beach, CALos Angeles, CA
Publicly tradedNoYes (NAGE)
Treatment categories71
Treatments listed131
Starting price$60/mo$149/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDNiagen Plus
Longevity & Peptides$100–$149
Glutathione
$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

He & She MD vs Niagen Plus — FAQ

Is He & She MD better than Niagen Plus?

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He & She MD scores higher overall in our independent evaluation (65.3/100 vs 64.7/100), leading on value, experience, product range. Niagen Plus comes out ahead on trust & safety, reputation.

Is He & She MD or Niagen Plus cheaper?

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He & She MD has the lower starting price (from $60/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and Niagen Plus both offer?

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Both platforms treat Longevity & Peptides. He & She MD covers 7 treatment categories total and Niagen Plus covers 1.

Still deciding?

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