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He & She MD vs Synergy Rx: Which Is Better?

Head-to-head comparison of He & She MD and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

He & She MD scores higher overall in our independent evaluation (65.3/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

65

He & She MD is a Newport Beach-based men's and women's telehealth brand covering GLP-1s, longevity injectables, HRT, testosterone, hair loss and ED, with the lowest prices tied to long prepaid terms.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionHe & She MDSynergy Rx
Overall Score65.3/100 ✓51.9/100
Trust & Safety30%58/100 ✓48/100
Value25%74/100 ✓60/100
Experience20%60/100 ✓50/100
Product Range15%84/100 ✓58/100
Reputation10%48/100 ✓38/100

At a Glance

Founded20252026
HeadquartersNewport Beach, CA—
Publicly tradedNoNo
Treatment categories73
Treatments listed139
Starting price$60/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHe & She MDSynergy Rx
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
$199
Compounded Semaglutide (injectable)
Longevity & Peptides$100–$149
Glutathione
$109
B12 Methylcobalamin
Sexual Health$60–$96
ED Treatment (on-demand, daily, combination)
$275
PT-141 (bremelanotide)

He & She MD

+Broad catalog covering compounded GLP-1s (injectable and oral), NAD+, sermorelin, glutathione, estradiol/progesterone HRT, testosterone, enclomiphene, hair loss and ED
+Names its dispensing pharmacies and the states where one partner cannot ship sterile compounds
+Low entry pricing on long terms: compounded semaglutide $99/mo on annual prepay, hair loss $79/mo, ED from $10/dose
−Site shows '4.8 Excellent' and 5.0 rating badges while its Trustpilot profile has zero reviews, so the ratings can't be verified
−Most headline prices require 3- to 12-month prepayment; month-to-month semaglutide is $199 and tirzepatide $299
−Platform terms allow a $15 fee per additional consult or lab-result interpretation on top of plan prices
Read the full He & She MD review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

He & She MD vs Synergy Rx — FAQ

Is He & She MD better than Synergy Rx?

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He & She MD scores higher overall in our independent evaluation (65.3/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is He & She MD or Synergy Rx cheaper?

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He & She MD has the lower starting price (from $60/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do He & She MD and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides, Sexual Health. He & She MD covers 7 treatment categories total and Synergy Rx covers 3.

Still deciding?

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