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Healthspan vs Niagen Plus: Which Is Better?

Head-to-head comparison of Healthspan and Niagen Plus based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Healthspan scores higher overall in our independent evaluation (71.3/100 vs 64.7/100), leading on experience, product range, reputation. Niagen Plus comes out ahead on trust & safety, value.

71

Healthspan is a Santa Monica-based longevity clinic built around clinician-guided rapamycin protocols, with add-on hormone, metabolic and brand-name GLP-1 care under a $99/mo membership.

Visit Healthspan
65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus

Score Breakdown

DimensionHealthspanNiagen Plus
Overall Score71.3/100 ✓64.7/100
Trust & Safety30%72/10078/100 ✓
Value25%68/10070/100 ✓
Experience20%72/100 ✓58/100
Product Range15%74/100 ✓36/100
Reputation10%72/100 ✓68/100

At a Glance

Founded20192024
HeadquartersSanta Monica, CALos Angeles, CA
Publicly tradedNoYes (NAGE)
Treatment categories71
Treatments listed141
Starting price$25/mo$149/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryHealthspanNiagen Plus
Longevity & Peptides$25
Acarbose
$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)

Healthspan

+Deepest rapamycin-centered longevity formulary we track: oral and topical rapamycin, SGLT2 inhibitors, metformin, acarbose, LDN and methylene blue
+Low entry pricing for core longevity drugs (rapamycin from $64/mo, metformin $27, acarbose $25), shown on the homepage
+Strong patient sentiment: 4.8/5 across ~402 Trustpilot reviews, with a founder who responds personally to negative reviews
−Brand-name GLP-1s require the $99+/mo membership on top of the medication cost ($299/mo Zepbound, $149/mo Wegovy pill)
−Longevity uses of rapamycin, SGLT2 inhibitors and metformin are off-label, and headline claims (e.g., an 8-year average biological-age reduction) are self-reported
−Dispensing pharmacy and medical group are not named on the public site
Read the full Healthspan review →

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

Healthspan vs Niagen Plus — FAQ

Is Healthspan better than Niagen Plus?

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Healthspan scores higher overall in our independent evaluation (71.3/100 vs 64.7/100), leading on experience, product range, reputation. Niagen Plus comes out ahead on trust & safety, value.

Is Healthspan or Niagen Plus cheaper?

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Healthspan has the lower starting price (from $25/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Healthspan and Niagen Plus both offer?

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Both platforms treat Longevity & Peptides. Healthspan covers 7 treatment categories total and Niagen Plus covers 1.

Still deciding?

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