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Josie vs ProlongMD: Which Is Better?

Head-to-head comparison of Josie and ProlongMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 57.6/100), leading on trust & safety, value, product range. Josie comes out ahead on experience.

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Josie
Fair

Small menopause-focused telehealth brand selling compounded and branded GLP-1s, microdose GLP-1 maintenance plans and estradiol/progesterone HRT at flat published prices.

Visit Josie
60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD

Score Breakdown

DimensionJosieProlongMD
Overall Score57.6/10060.1/100 ✓
Trust & Safety30%50/10052/100 ✓
Value25%70/10074/100 ✓
Experience20%58/100 ✓55/100
Product Range15%60/10070/100 ✓
Reputation10%45/10045/100

At a Glance

Founded—2025
Headquarters—Phoenix, AZ
Publicly tradedNoNo
Treatment categories38
Treatments listed713
Starting price$90/mo$25/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryJosieProlongMD
Women's Health—$33
Progesterone (oral)
Hormone Therapy$90–$100
Estradiol Patch or Cream (HRT)
$89–$119
Testosterone Cypionate (200 mg/mL)
Weight Loss / GLP-1$189
Microdose GLP-1 Maintenance (semaglutide or tirzepatide)
$99–$119
Compounded Semaglutide/B12

Josie

+Flat pricing at any dose, published before intake: compounded semaglutide $249/mo ($194/mo prepaid annually), tirzepatide $349/mo ($233/mo annually)
+Offers injectable, oral ODT and microdose ($189/mo) GLP-1 formats alongside HRT in one women's-midlife intake
+Names its lead clinician (Dr. Ana Lisa Carr, MD, board-certified in family medicine) and says it serves all 50 states
−FDA warning letter (Feb 20, 2026) for misbranded compounded semaglutide/tirzepatide marketing
−White-label setup: Josie is a trade name of One Eleven Nutrition LLC on the CareValidate platform, and its terms say it doesn't control provider decisions
−An $80 consultation fee applies if a provider approves a plan and the patient declines medication, and filled orders are non-refundable
Read the full Josie review →

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

Josie vs ProlongMD — FAQ

Is Josie better than ProlongMD?

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ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 57.6/100), leading on trust & safety, value, product range. Josie comes out ahead on experience.

Is Josie or ProlongMD cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $90/mo for Josie). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Josie and ProlongMD both offer?

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Both platforms treat Women's Health, Hormone Therapy, Weight Loss / GLP-1. Josie covers 3 treatment categories total and ProlongMD covers 8.

Still deciding?

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