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Josie vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Josie and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 57.6/100), leading on trust & safety, value, experience, product range, reputation.

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Josie
Fair

Small menopause-focused telehealth brand selling compounded and branded GLP-1s, microdose GLP-1 maintenance plans and estradiol/progesterone HRT at flat published prices.

Visit Josie
75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionJosieTwentyeight Health
Overall Score57.6/10075/100 ✓
Trust & Safety30%50/10076/100 ✓
Value25%70/10080/100 ✓
Experience20%58/10072/100 ✓
Product Range15%60/10072/100 ✓
Reputation10%45/10070/100 ✓

At a Glance

Founded—2018
Headquarters—Brooklyn, NY
Publicly tradedNoNo
Treatment categories34
Treatments listed77
Starting price$90/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryJosieTwentyeight Health
Women's Health—$15–$19.99
Complete Care Membership
Weight Loss / GLP-1$189
Microdose GLP-1 Maintenance (semaglutide or tirzepatide)
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Josie

+Flat pricing at any dose, published before intake: compounded semaglutide $249/mo ($194/mo prepaid annually), tirzepatide $349/mo ($233/mo annually)
+Offers injectable, oral ODT and microdose ($189/mo) GLP-1 formats alongside HRT in one women's-midlife intake
+Names its lead clinician (Dr. Ana Lisa Carr, MD, board-certified in family medicine) and says it serves all 50 states
−FDA warning letter (Feb 20, 2026) for misbranded compounded semaglutide/tirzepatide marketing
−White-label setup: Josie is a trade name of One Eleven Nutrition LLC on the CareValidate platform, and its terms say it doesn't control provider decisions
−An $80 consultation fee applies if a provider approves a plan and the patient declines medication, and filled orders are non-refundable
Read the full Josie review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Josie vs Twentyeight Health — FAQ

Is Josie better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 57.6/100), leading on trust & safety, value, experience, product range, reputation.

Is Josie or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $90/mo for Josie). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Josie and Twentyeight Health both offer?

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Both platforms treat Women's Health, Weight Loss / GLP-1. Josie covers 3 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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