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MadeMed vs Synergy Rx: Which Is Better?

Head-to-head comparison of MadeMed and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

MadeMed scores higher overall in our independent evaluation (57.3/100 vs 51.9/100), leading on trust & safety, value, product range, reputation. Synergy Rx comes out ahead on experience.

57

MadeMed is a Houston-registered telehealth brand selling compounded injectable and oral GLP-1s, sermorelin, NAD+ and tadalafil through the Xpedicare provider network.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionMadeMedSynergy Rx
Overall Score57.3/100 ✓51.9/100
Trust & Safety30%55/100 ✓48/100
Value25%66/100 ✓60/100
Experience20%45/10050/100 ✓
Product Range15%72/100 ✓58/100
Reputation10%45/100 ✓38/100

At a Glance

Founded—2026
HeadquartersHouston, TX—
Publicly tradedNoNo
Treatment categories33
Treatments listed79
Starting price$30/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryMadeMedSynergy Rx
Weight Loss / GLP-1$99–$199
Compounded Semaglutide (injectable)
$199
Compounded Semaglutide (injectable)
Longevity & Peptides$129–$229
Sermorelin (injectable or oral)
$109
B12 Methylcobalamin
Sexual Health$30–$90
Tadalafil
$275
PT-141 (bremelanotide)

MadeMed

+Offers both injectable and oral/sublingual versions of semaglutide, tirzepatide and sermorelin, plus NAD+ as injection or nasal spray
+Operating entity, provider network (Xpedicare) and a partner pharmacy (Red Rock) are named in the terms and About page
+Advertised GLP-1 entry pricing from $99/mo is at the low end of the market
−Product pages showed no pricing or product detail during our research, in a direct fetch or a real browser
−Advertised prices and state coverage (about 40 states) come from brand-issued press releases and can't be verified on-site
−No Trustpilot or other independent patient reviews; public coverage is mostly paid newswire content
Read the full MadeMed review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

MadeMed vs Synergy Rx — FAQ

Is MadeMed better than Synergy Rx?

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MadeMed scores higher overall in our independent evaluation (57.3/100 vs 51.9/100), leading on trust & safety, value, product range, reputation. Synergy Rx comes out ahead on experience.

Is MadeMed or Synergy Rx cheaper?

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MadeMed has the lower starting price (from $30/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do MadeMed and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides, Sexual Health. MadeMed covers 3 treatment categories total and Synergy Rx covers 3.

Still deciding?

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