Home›Compare›Natural Cycles vs ProlongMD

Natural Cycles vs ProlongMD: Which Is Better?

Head-to-head comparison of Natural Cycles and ProlongMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Natural Cycles scores higher overall in our independent evaluation (67.4/100 vs 60.1/100), leading on trust & safety, value, experience, reputation. ProlongMD comes out ahead on product range.

67

FDA-cleared, hormone-free digital contraceptive that uses temperature data from a thermometer or wearable to flag fertile days; it involves no clinician or prescription.

Visit Natural Cycles
60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD

Score Breakdown

DimensionNatural CyclesProlongMD
Overall Score67.4/100 ✓60.1/100
Trust & Safety30%70/100 ✓52/100
Value25%76/100 ✓74/100
Experience20%72/100 ✓55/100
Product Range15%45/10070/100 ✓
Reputation10%62/100 ✓45/100

At a Glance

Founded20132025
HeadquartersStockholm, SwedenPhoenix, AZ
Publicly tradedNoNo
Treatment categories18
Treatments listed113
Starting price$12.5/mo$25/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryNatural CyclesProlongMD
Women's Health$12.5
NC° Birth Control (annual plan incl. NC° Band)
$33
Progesterone (oral)

Natural Cycles

+Only FDA-cleared digital contraceptive (Class II De Novo, 2018), with no hormones or side effects
+Low all-in cost: about $150/year including the NC° Band wearable, HSA/FSA-eligible
+Works with existing wearables (Oura, Apple Watch Series 8+, Garmin) and switches between contraception, conception, pregnancy, postpartum and perimenopause modes at no extra charge
−Typical-use effectiveness is 93%, below IUDs and implants, and depends on daily measurement and abstaining or using protection on fertile days
−No clinician involvement or prescription options; not a substitute for a birth-control prescriber
−December 2025 class action alleges reproductive-health data was shared with third-party trackers without consent
Read the full Natural Cycles review →

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

Natural Cycles vs ProlongMD — FAQ

Is Natural Cycles better than ProlongMD?

▾

Natural Cycles scores higher overall in our independent evaluation (67.4/100 vs 60.1/100), leading on trust & safety, value, experience, reputation. ProlongMD comes out ahead on product range.

Is Natural Cycles or ProlongMD cheaper?

▾

Natural Cycles has the lower starting price (from $12.5/mo vs $25/mo for ProlongMD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Natural Cycles and ProlongMD both offer?

▾

Both platforms treat Women's Health. Natural Cycles covers 1 treatment category total and ProlongMD covers 8.

Still deciding?

Natural Cycles alternativesProlongMD alternativesTake the Match Quiz