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Niagen Plus vs ProlongMD: Which Is Better?

Head-to-head comparison of Niagen Plus and ProlongMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 60.1/100), leading on trust & safety, experience, reputation. ProlongMD comes out ahead on value, product range. ProlongMD has the lower entry price (from $25/mo vs $149/mo), so the better value depends on which treatment you need.

Niagen Plus

Fair

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus

ProlongMD

Fair

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

Visit ProlongMD

Score Breakdown

Dimension	Niagen Plus	ProlongMD
Overall Score	64.7/100 ✓	60.1/100
Trust & Safety30%	78/100 ✓	52/100
Value25%	70/100	74/100 ✓
Experience20%	58/100 ✓	55/100
Product Range15%	36/100	70/100 ✓
Reputation10%	68/100 ✓	45/100

At a Glance

Founded	2024	2025
Headquarters	Los Angeles, CA	Phoenix, AZ
Publicly traded	Yes (NAGE)	No
Treatment categories	1	8
Treatments listed	1	13
Starting price	$149/mo	$25/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

Category	Niagen Plus	ProlongMD
Longevity & Peptides	$149 Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)	$179 Sermorelin

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)

+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone

+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping

−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored

−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable

−The site does not name the telehealth medical group or the dispensing 503A pharmacy

Read the full Niagen Plus review →

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee

+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs

+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits

−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form

−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)

−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text

Read the full ProlongMD review →

Niagen Plus vs ProlongMD — FAQ

Is Niagen Plus better than ProlongMD?

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Is Niagen Plus or ProlongMD cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Niagen Plus and ProlongMD both offer?

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Both platforms treat Longevity & Peptides. Niagen Plus covers 1 treatment category total and ProlongMD covers 8.

Still deciding?

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