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Niagen Plus vs RxSpan MD: Which Is Better?

Head-to-head comparison of Niagen Plus and RxSpan MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range. RxSpan MD has the lower entry price (from $30/mo vs $149/mo), so the better value depends on which treatment you need.

65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus
59

RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

Visit RxSpan MD

Score Breakdown

DimensionNiagen PlusRxSpan MD
Overall Score64.7/100 ✓59.1/100
Trust & Safety30%78/100 ✓60/100
Value25%70/100 ✓58/100
Experience20%58/100 ✓52/100
Product Range15%36/10078/100 ✓
Reputation10%68/100 ✓45/100

At a Glance

Founded20242026
HeadquartersLos Angeles, CABeverly Hills, CA
Publicly tradedYes (NAGE)No
Treatment categories14
Treatments listed19
Starting price$149/mo$30/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryNiagen PlusRxSpan MD
Longevity & Peptides$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)
$100–$200
Glutathione

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

Niagen Plus vs RxSpan MD — FAQ

Is Niagen Plus better than RxSpan MD?

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Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 59.1/100), leading on trust & safety, value, experience, reputation. RxSpan MD comes out ahead on product range. RxSpan MD has the lower entry price (from $30/mo vs $149/mo), so the better value depends on which treatment you need.

Is Niagen Plus or RxSpan MD cheaper?

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RxSpan MD has the lower starting price (from $30/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Niagen Plus and RxSpan MD both offer?

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Both platforms treat Longevity & Peptides. Niagen Plus covers 1 treatment category total and RxSpan MD covers 4.

Still deciding?

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