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Niagen Plus vs Shed: Which Is Better?

Head-to-head comparison of Niagen Plus and Shed based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Shed scores higher overall in our independent evaluation (67/100 vs 64.7/100), leading on experience, product range. Niagen Plus comes out ahead on trust & safety, reputation.

65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus
67
Shed
Good

Weight loss, hair loss, and longevity telehealth with multiple GLP-1 delivery formats including drops, lozenges, and oral tablets.

Visit Shed

Score Breakdown

DimensionNiagen PlusShed
Overall Score64.7/10067/100 ✓
Trust & Safety30%78/100 ✓60/100
Value25%70/10070/100
Experience20%58/10070/100 ✓
Product Range15%36/10072/100 ✓
Reputation10%68/100 ✓62/100

At a Glance

Founded20242022
HeadquartersLos Angeles, CAGilbert, AZ
Publicly tradedYes (NAGE)No
Treatment categories13
Treatments listed113
Starting price$149/mo$43/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryNiagen PlusShed
Longevity & Peptides$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)
$115
MIC + B12 Injections

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

Shed

+Widest variety of GLP-1 delivery formats: injections, drops, lozenges, and oral tablets
+Both compounded and brand-name GLP-1 options (Wegovy, Zepbound) available
+10% body weight loss guarantee or money back
−Two-month minimum commitment before cancellation allowed
−Cash-pay only — no insurance accepted
−BBB rating 2.87/5 (not accredited) with billing and cancellation complaints
Read the full Shed review →

Niagen Plus vs Shed — FAQ

Is Niagen Plus better than Shed?

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Shed scores higher overall in our independent evaluation (67/100 vs 64.7/100), leading on experience, product range. Niagen Plus comes out ahead on trust & safety, reputation.

Is Niagen Plus or Shed cheaper?

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Shed has the lower starting price (from $43/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Niagen Plus and Shed both offer?

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Both platforms treat Longevity & Peptides. Niagen Plus covers 1 treatment category total and Shed covers 3.

Still deciding?

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