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Niagen Plus vs Wellorithm: Which Is Better?

Head-to-head comparison of Niagen Plus and Wellorithm based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 54.8/100), leading on trust & safety, value, experience, reputation. Wellorithm comes out ahead on product range.

65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

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55
Wellorithm
Below Average

Wellorithm is a Miami-based GLP-1 platform that sells compounded semaglutide ($147 first month, then $247 per 28 days) and tirzepatide ($249, then $349), and also lists branded GLP-1s, NAD+, sermorelin and tadalafil.

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Score Breakdown

DimensionNiagen PlusWellorithm
Overall Score64.7/100 ✓54.8/100
Trust & Safety30%78/100 ✓45/100
Value25%70/100 ✓68/100
Experience20%58/100 ✓55/100
Product Range15%36/10065/100 ✓
Reputation10%68/100 ✓35/100

At a Glance

Founded20242025
HeadquartersLos Angeles, CAMiami, FL
Publicly tradedYes (NAGE)No
Treatment categories14
Treatments listed12
Starting price$149/mo$247/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryNiagen PlusWellorithm
Longevity & Peptides$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)
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Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

Wellorithm

+First-month pricing is competitive: compounded semaglutide $147 and tirzepatide $249, with no membership fee and free shipping
+Written weight-loss guarantee: refund of up to four months of fees if a new patient loses less than 10% after 16 adherent weeks (terms apply)
+Broad catalog spanning compounded injectables and tablets, branded GLP-1s, NAD+, sermorelin and tadalafil
−Ongoing prices rise $100 after month one ($247 / $349), and 28-day billing means 13 charges a year
−Medical group and dispensing pharmacy are not named, and the About page shows placeholder 'specialist' profiles with no credentials
−The site advertises a 4.5 Trustpilot score that doesn't match its thin actual Trustpilot profile, which includes a report of an unauthorized $899 charge and a delayed refund
Read the full Wellorithm review →

Niagen Plus vs Wellorithm — FAQ

Is Niagen Plus better than Wellorithm?

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Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 54.8/100), leading on trust & safety, value, experience, reputation. Wellorithm comes out ahead on product range.

Is Niagen Plus or Wellorithm cheaper?

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Niagen Plus has the lower starting price (from $149/mo vs $247/mo for Wellorithm). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Niagen Plus and Wellorithm both offer?

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Both platforms treat Longevity & Peptides. Niagen Plus covers 1 treatment category total and Wellorithm covers 4.

Still deciding?

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