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Niagen Plus vs Yucca Health: Which Is Better?

Head-to-head comparison of Niagen Plus and Yucca Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Yucca Health scores higher overall in our independent evaluation (68.3/100 vs 64.7/100), leading on value, experience, product range. Niagen Plus comes out ahead on trust & safety, reputation.

65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus
68

Yucca Health is a Beverly Hills-based telehealth platform selling compounded semaglutide and tirzepatide at flat, dose-independent prices, plus compounded NAD+ and sermorelin.

Visit Yucca Health

Score Breakdown

DimensionNiagen PlusYucca Health
Overall Score64.7/10068.3/100 ✓
Trust & Safety30%78/100 ✓64/100
Value25%70/10080/100 ✓
Experience20%58/10072/100 ✓
Product Range15%36/10058/100 ✓
Reputation10%68/100 ✓60/100

At a Glance

Founded20242025
HeadquartersLos Angeles, CABeverly Hills, CA
Publicly tradedYes (NAGE)No
Treatment categories12
Treatments listed14
Starting price$149/mo$125/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryNiagen PlusYucca Health
Longevity & Peptides$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)
$158–$215
NAD+ Injection

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

Yucca Health

+Full price grid published before intake: semaglutide $146/mo monthly, $140/mo quarterly or $125/mo on a 6-month prepay; tirzepatide $258, $248 or $225/mo
+Locked pricing covers the whole dose range, so titrating up does not raise the bill; pausing keeps the locked rate
+No separate membership or consultation fee; plans include the provider consult, medication, injection supplies and free 2-day shipping
−Dispensing pharmacies are not named on the public site; they appear only in the patient portal and on the label after ordering
−BBB rating of C+ (not accredited) with five closed complaints; one Trustpilot reviewer reports prepaying six months and receiving three
−About 6% of roughly 1,230 Trustpilot reviews are 1-star, citing lack of results after months of treatment and refund disputes
Read the full Yucca Health review →

Niagen Plus vs Yucca Health — FAQ

Is Niagen Plus better than Yucca Health?

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Yucca Health scores higher overall in our independent evaluation (68.3/100 vs 64.7/100), leading on value, experience, product range. Niagen Plus comes out ahead on trust & safety, reputation.

Is Niagen Plus or Yucca Health cheaper?

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Yucca Health has the lower starting price (from $125/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Niagen Plus and Yucca Health both offer?

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Both platforms treat Longevity & Peptides. Niagen Plus covers 1 treatment category total and Yucca Health covers 2.

Still deciding?

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