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ProlongMD vs Synergy Rx: Which Is Better?

Head-to-head comparison of ProlongMD and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

60

Small, veteran-owned cash-pay telehealth practice offering compounded GLP-1s, TRT, enclomiphene, women's hormones, ED, hair loss and peptides after a $79 video consult.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionProlongMDSynergy Rx
Overall Score60.1/100 ✓51.9/100
Trust & Safety30%52/100 ✓48/100
Value25%74/100 ✓60/100
Experience20%55/100 ✓50/100
Product Range15%70/100 ✓58/100
Reputation10%45/100 ✓38/100

At a Glance

Founded20252026
HeadquartersPhoenix, AZ—
Publicly tradedNoNo
Treatment categories83
Treatments listed139
Starting price$25/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryProlongMDSynergy Rx
Weight Loss / GLP-1$99–$119
Compounded Semaglutide/B12
$199
Compounded Semaglutide (injectable)
Sexual Health$75
Tadalafil 24 mg
$275
PT-141 (bremelanotide)
Longevity & Peptides$179
Sermorelin
$109
B12 Methylcobalamin

ProlongMD

+Low published prices: compounded semaglutide/B12 from $99/mo and tirzepatide/B12 from $149/mo, with no membership fee
+$79 video consult is credited toward the first treatment purchase, and a written price-match policy covers comparable injectable programs
+Names its prescribing clinicians (two physicians, two nurse practitioners) and runs synchronous video visits
−Sells BPC-157/TB-500 and GHK-Cu/BPC-157/KPV/TB-500 'peptide blends', compounds the FDA has flagged for safety concerns and which have no approved drug form
−Dispensing pharmacies are not named, and the states served are not published (visible reviews come only from TX and CO)
−Very new (LLC formed August 2025) with no independent review footprint; several on-site star ratings have no review text
Read the full ProlongMD review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

ProlongMD vs Synergy Rx — FAQ

Is ProlongMD better than Synergy Rx?

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ProlongMD scores higher overall in our independent evaluation (60.1/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is ProlongMD or Synergy Rx cheaper?

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ProlongMD has the lower starting price (from $25/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do ProlongMD and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health, Longevity & Peptides. ProlongMD covers 8 treatment categories total and Synergy Rx covers 3.

Still deciding?

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