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Rex MD vs Synergy Rx: Which Is Better?

Head-to-head comparison of Rex MD and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Rex MD scores higher overall in our independent evaluation (72.2/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

72
Rex MD
Good

Rex MD is a men's-health telehealth brand — owned by publicly traded LifeMD — covering ED, premature ejaculation, TRT, hair loss, and GLP-1 treatment.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionRex MDSynergy Rx
Overall Score72.2/100 ✓51.9/100
Trust & Safety30%78/100 ✓48/100
Value25%65/100 ✓60/100
Experience20%68/100 ✓50/100
Product Range15%78/100 ✓58/100
Reputation10%72/100 ✓38/100

At a Glance

Founded20192026
HeadquartersNew York, NY—
Publicly tradedNoNo
Treatment categories53
Treatments listed69
Starting price$2/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryRex MDSynergy Rx
Sexual Health$2–$90
Sildenafil / Tadalafil (generic & brand)
$275
PT-141 (bremelanotide)
Weight Loss / GLP-1$199–$399
GLP-1 Weight Loss
$199
Compounded Semaglutide (injectable)

Rex MD

+Backed by LifeMD, a publicly traded parent company, giving it more financial and compliance infrastructure than an independent startup
+Strong Trustpilot rating (4.7/5, 5,259 reviews) with consistent praise for customer service staff
+Wide medication range across ED, premature ejaculation, TRT, hair loss, and GLP-1s under one account
−Recurring patient complaints about surprise auto-renewal charges not clearly disclosed at checkout
−Shipping and fulfillment issues reported, including incorrect dosing and underfilled vials
−Headline 'as low as $2/dose' pricing is a teaser rate; full pricing isn't shown until after intake
Read the full Rex MD review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Rex MD vs Synergy Rx — FAQ

Is Rex MD better than Synergy Rx?

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Rex MD scores higher overall in our independent evaluation (72.2/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is Rex MD or Synergy Rx cheaper?

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Rex MD has the lower starting price (from $2/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Rex MD and Synergy Rx both offer?

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Both platforms treat Sexual Health, Weight Loss / GLP-1. Rex MD covers 5 treatment categories total and Synergy Rx covers 3.

Still deciding?

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