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RxSpan MD vs Synergy Rx: Which Is Better?

Head-to-head comparison of RxSpan MD and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

RxSpan MD scores higher overall in our independent evaluation (59.1/100 vs 51.9/100), leading on trust & safety, experience, product range, reputation. Synergy Rx comes out ahead on value.

59

RxSpan MD is a Beverly Hills telehealth practice founded by a plastic surgeon, offering compounded and branded GLP-1s, longevity peptides, hair-loss and ED treatment.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionRxSpan MDSynergy Rx
Overall Score59.1/100 ✓51.9/100
Trust & Safety30%60/100 ✓48/100
Value25%58/10060/100 ✓
Experience20%52/100 ✓50/100
Product Range15%78/100 ✓58/100
Reputation10%45/100 ✓38/100

At a Glance

Founded20262026
HeadquartersBeverly Hills, CA—
Publicly tradedNoNo
Treatment categories43
Treatments listed99
Starting price$30/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryRxSpan MDSynergy Rx
Weight Loss / GLP-1$249–$299
Compounded Semaglutide (injection or oral)
$199
Compounded Semaglutide (injectable)
Longevity & Peptides$100–$200
Glutathione
$109
B12 Methylcobalamin
Sexual Health$30–$100
ED (tadalafil, sildenafil/pycnogenol, vardenafil)
$275
PT-141 (bremelanotide)

RxSpan MD

+Physician-founded practice with a named founder and a stated Beverly Hills address
+Offers both compounded (injection and oral) and branded GLP-1s, including cash-pay Zepbound listed at $500
+Third-party coverage reports named 503A pharmacy partners and free expedited shipping
−Compounded prices aren't visible on the public site; its product catalog failed to load during our research
−Brand-stated first-month prices ($249 semaglutide, $329 tirzepatide) are above peer averages, and renewal pricing is not published
−Site configuration shows an $80 initial visit fee that is not prominently disclosed
Read the full RxSpan MD review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

RxSpan MD vs Synergy Rx — FAQ

Is RxSpan MD better than Synergy Rx?

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RxSpan MD scores higher overall in our independent evaluation (59.1/100 vs 51.9/100), leading on trust & safety, experience, product range, reputation. Synergy Rx comes out ahead on value.

Is RxSpan MD or Synergy Rx cheaper?

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RxSpan MD has the lower starting price (from $30/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do RxSpan MD and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides, Sexual Health. RxSpan MD covers 4 treatment categories total and Synergy Rx covers 3.

Still deciding?

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