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Sesame Care vs Synergy Rx: Which Is Better?

Head-to-head comparison of Sesame Care and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Sesame Care scores higher overall in our independent evaluation (74/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

74

Pay-per-visit marketplace connecting patients with licensed providers — no subscriptions, transparent per-visit pricing.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionSesame CareSynergy Rx
Overall Score74/100 ✓51.9/100
Trust & Safety30%75/100 ✓48/100
Value25%80/100 ✓60/100
Experience20%70/100 ✓50/100
Product Range15%70/100 ✓58/100
Reputation10%70/100 ✓38/100

At a Glance

Founded20192026
HeadquartersNew York, NY—
Publicly tradedNoNo
Treatment categories63
Treatments listed79
Starting price$11/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategorySesame CareSynergy Rx
Weight Loss / GLP-1$59–$99
Weight Loss Program (subscription)
$199
Compounded Semaglutide (injectable)

Sesame Care

+No subscription required — pay-per-visit model
+Transparent pricing shown before booking
+Wide range of specialties available
−No integrated pharmacy
−Less continuity of care than subscriptions
−Provider quality varies in marketplace model
Read the full Sesame Care review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Sesame Care vs Synergy Rx — FAQ

Is Sesame Care better than Synergy Rx?

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Sesame Care scores higher overall in our independent evaluation (74/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is Sesame Care or Synergy Rx cheaper?

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Sesame Care has the lower starting price (from $11/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Sesame Care and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1. Sesame Care covers 6 treatment categories total and Synergy Rx covers 3.

Still deciding?

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