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Shameless Care vs Synergy Rx: Which Is Better?

Head-to-head comparison of Shameless Care and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Shameless Care scores higher overall in our independent evaluation (66/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

66

Shameless Care is an Illinois sexual-health telehealth company selling ED and female-arousal medications, comprehensive STI testing, DoxyPEP and UTI/BV/yeast treatment as one-time purchases.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionShameless CareSynergy Rx
Overall Score66/100 ✓51.9/100
Trust & Safety30%68/100 ✓48/100
Value25%68/100 ✓60/100
Experience20%66/100 ✓50/100
Product Range15%66/100 ✓58/100
Reputation10%55/100 ✓38/100

At a Glance

Founded20222026
HeadquartersSt. Charles, IL—
Publicly tradedNoNo
Treatment categories43
Treatments listed109
Starting price$63/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryShameless CareSynergy Rx
Sexual Health$99–$199
DoxyPEP
$275
PT-141 (bremelanotide)

Shameless Care

+One-time purchases with no auto-renewal, which avoids the recurring-charge complaints common in the category
+Every price is posted on the site, all-in with consult, prescription and shipping (e.g. UTI treatment $63, Shameless Duo from $130)
+Covers men's and women's sexual health, including STI testing, DoxyPEP, herpes suppression and female arousal treatments, which most ED-focused brands don't
−Two of its three named partner pharmacies (Curexa, Belmar) received FDA compounding warning letters in 2023
−Review evidence is mostly the brand's own on-site testimonials; little independent Trustpilot or Reddit footprint
−Compounded ED troches cost about $7–11 per dose, well above generic sildenafil or tadalafil tablets
Read the full Shameless Care review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Shameless Care vs Synergy Rx — FAQ

Is Shameless Care better than Synergy Rx?

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Shameless Care scores higher overall in our independent evaluation (66/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is Shameless Care or Synergy Rx cheaper?

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Shameless Care has the lower starting price (from $63/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Shameless Care and Synergy Rx both offer?

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Both platforms treat Sexual Health. Shameless Care covers 4 treatment categories total and Synergy Rx covers 3.

Still deciding?

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