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Shed vs Synergy Rx: Which Is Better?

Head-to-head comparison of Shed and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Shed scores higher overall in our independent evaluation (67/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

67
Shed
Good

Weight loss, hair loss, and longevity telehealth with multiple GLP-1 delivery formats including drops, lozenges, and oral tablets.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionShedSynergy Rx
Overall Score67/100 ✓51.9/100
Trust & Safety30%60/100 ✓48/100
Value25%70/100 ✓60/100
Experience20%70/100 ✓50/100
Product Range15%72/100 ✓58/100
Reputation10%62/100 ✓38/100

At a Glance

Founded20222026
HeadquartersGilbert, AZ—
Publicly tradedNoNo
Treatment categories33
Treatments listed139
Starting price$43/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryShedSynergy Rx
Weight Loss / GLP-1$115
Naltrexone + Bupropion Capsules
$199
Compounded Semaglutide (injectable)
Longevity & Peptides$115
MIC + B12 Injections
$109
B12 Methylcobalamin

Shed

+Widest variety of GLP-1 delivery formats: injections, drops, lozenges, and oral tablets
+Both compounded and brand-name GLP-1 options (Wegovy, Zepbound) available
+10% body weight loss guarantee or money back
−Two-month minimum commitment before cancellation allowed
−Cash-pay only — no insurance accepted
−BBB rating 2.87/5 (not accredited) with billing and cancellation complaints
Read the full Shed review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Shed vs Synergy Rx — FAQ

Is Shed better than Synergy Rx?

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Shed scores higher overall in our independent evaluation (67/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is Shed or Synergy Rx cheaper?

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Shed has the lower starting price (from $43/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Shed and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Shed covers 3 treatment categories total and Synergy Rx covers 3.

Still deciding?

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