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Synergy Rx vs Twentyeight Health: Which Is Better?

Head-to-head comparison of Synergy Rx and Twentyeight Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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75

Brooklyn-based women's telehealth service covering birth control, emergency contraception, UTI/BV/yeast and herpes treatment, prescription skincare and branded GLP-1s under a $19.99/mo membership ($0 in-network).

Visit Twentyeight Health

Score Breakdown

DimensionSynergy RxTwentyeight Health
Overall Score51.9/10075/100 ✓
Trust & Safety30%48/10076/100 ✓
Value25%60/10080/100 ✓
Experience20%50/10072/100 ✓
Product Range15%58/10072/100 ✓
Reputation10%38/10070/100 ✓

At a Glance

Founded20262018
Headquarters—Brooklyn, NY
Publicly tradedNoNo
Treatment categories34
Treatments listed97
Starting price$109/mo$15/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategorySynergy RxTwentyeight Health
Weight Loss / GLP-1$199
Compounded Semaglutide (injectable)
—
Sexual Health$275
PT-141 (bremelanotide)
—

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Twentyeight Health

+Low entry cost: $19.99/mo membership ($0 when in-network), birth control from $16/pack cash and often $0 with insurance
+Accepts most commercial insurance and Medicaid in multiple states, which few D2C telehealth brands do
+One membership covers contraception, EC, UTI/BV/yeast, herpes, skincare and weight care, and urgent-care prescriptions are ready for pickup in 4–6 hours
−Medications are billed separately from the membership, which some reviewers say caused unexpected charges
−Weight care (branded Wegovy/Zepbound only) is limited to about 22 states, and skincare to a subset of states
−21% of Trustpilot reviews are 1-star, citing billing discrepancies and support communication problems
Read the full Twentyeight Health review →

Synergy Rx vs Twentyeight Health — FAQ

Is Synergy Rx better than Twentyeight Health?

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Twentyeight Health scores higher overall in our independent evaluation (75/100 vs 51.9/100), leading on trust & safety, value, experience, product range, reputation.

Is Synergy Rx or Twentyeight Health cheaper?

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Twentyeight Health has the lower starting price (from $15/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Synergy Rx and Twentyeight Health both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. Synergy Rx covers 3 treatment categories total and Twentyeight Health covers 4.

Still deciding?

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