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Synergy Rx vs Willow: Which Is Better?

Head-to-head comparison of Synergy Rx and Willow based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Synergy Rx scores higher overall in our independent evaluation (51.9/100 vs 51.9/100), leading on value, product range. Willow comes out ahead on experience.

52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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52
Willow
Below Average

Women-focused compounded GLP-1 telehealth brand operating in a limited number of states, tied to a National Advertising Division referral over its marketing claims.

Visit Willow

Score Breakdown

DimensionSynergy RxWillow
Overall Score51.9/10051.9/100
Trust & Safety30%48/10048/100
Value25%60/100 ✓52/100
Experience20%50/10062/100 ✓
Product Range15%58/100 ✓55/100
Reputation10%38/10038/100

At a Glance

Founded2026—
Headquarters——
Publicly tradedNoNo
Treatment categories32
Treatments listed92
Starting price$109/mo$299/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategorySynergy RxWillow
Weight Loss / GLP-1$199
Compounded Semaglutide (injectable)
$299
Compounded Semaglutide

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Willow

+Women-focused positioning with unlimited doctor access included in plan price
+Reviewers highlight responsive, board-certified doctors and simple onboarding
+Some patients report substantial results (e.g., 65 lbs in three months)
−Reportedly referred by the National Advertising Division to state attorneys general (Dec 2025) over advertising claims — unverified independently this cycle, needs manual confirmation
−Service limited to a narrow footprint (reportedly ~12 states), well below most national competitors
−Pricing ($299-399/mo starting) runs higher than several direct compounded-GLP-1 competitors
Read the full Willow review →

Synergy Rx vs Willow — FAQ

Is Synergy Rx better than Willow?

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Synergy Rx scores higher overall in our independent evaluation (51.9/100 vs 51.9/100), leading on value, product range. Willow comes out ahead on experience.

Is Synergy Rx or Willow cheaper?

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Synergy Rx has the lower starting price (from $109/mo vs $299/mo for Willow). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Synergy Rx and Willow both offer?

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Both platforms treat Weight Loss / GLP-1. Synergy Rx covers 3 treatment categories total and Willow covers 2.

Still deciding?

Synergy Rx alternativesWillow alternativesTake the Match Quiz