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Synergy Rx vs Yucca Health: Which Is Better?

Head-to-head comparison of Synergy Rx and Yucca Health based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Yucca Health scores higher overall in our independent evaluation (68.3/100 vs 51.9/100), leading on trust & safety, value, experience, reputation. Synergy Rx has the lower entry price (from $109/mo vs $125/mo), so the better value depends on which treatment you need.

52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

Visit Synergy Rx

Yucca Health is a Beverly Hills-based telehealth platform selling compounded semaglutide and tirzepatide at flat, dose-independent prices, plus compounded NAD+ and sermorelin.

Visit Yucca Health

Score Breakdown

DimensionSynergy RxYucca Health
Overall Score51.9/10068.3/100 ✓
Trust & Safety30%48/10064/100 ✓
Value25%60/10080/100 ✓
Experience20%50/10072/100 ✓
Product Range15%58/10058/100
Reputation10%38/10060/100 ✓

At a Glance

Founded20262025
Headquarters—Beverly Hills, CA
Publicly tradedNoNo
Treatment categories32
Treatments listed94
Starting price$109/mo$125/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategorySynergy RxYucca Health
Weight Loss / GLP-1$199
Compounded Semaglutide (injectable)
$125–$146
Compounded Semaglutide+ (injectable)
Longevity & Peptides$109
B12 Methylcobalamin
$158–$215
NAD+ Injection

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Yucca Health

+Full price grid published before intake: semaglutide $146/mo monthly, $140/mo quarterly or $125/mo on a 6-month prepay; tirzepatide $258, $248 or $225/mo
+Locked pricing covers the whole dose range, so titrating up does not raise the bill; pausing keeps the locked rate
+No separate membership or consultation fee; plans include the provider consult, medication, injection supplies and free 2-day shipping
−Dispensing pharmacies are not named on the public site; they appear only in the patient portal and on the label after ordering
−BBB rating of C+ (not accredited) with five closed complaints; one Trustpilot reviewer reports prepaying six months and receiving three
−About 6% of roughly 1,230 Trustpilot reviews are 1-star, citing lack of results after months of treatment and refund disputes
Read the full Yucca Health review →

Synergy Rx vs Yucca Health — FAQ

Is Synergy Rx better than Yucca Health?

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Yucca Health scores higher overall in our independent evaluation (68.3/100 vs 51.9/100), leading on trust & safety, value, experience, reputation. Synergy Rx has the lower entry price (from $109/mo vs $125/mo), so the better value depends on which treatment you need.

Is Synergy Rx or Yucca Health cheaper?

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Synergy Rx has the lower starting price (from $109/mo vs $125/mo for Yucca Health). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Synergy Rx and Yucca Health both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Synergy Rx covers 3 treatment categories total and Yucca Health covers 2.

Still deciding?