Rapamycin Online
Brand names: Rapamune
Rapamycin (sirolimus) is an FDA-approved immunosuppressant used to prevent kidney transplant rejection and to treat lymphangioleiomyomatosis (LAM). It is the most consistently effective lifespan-extending drug in mouse studies, which has made low-dose, intermittent rapamycin one of the most common off-label longevity prescriptions. Human evidence for longevity benefit is early and unproven.
How Rapamycin Works
Rapamycin inhibits mTOR (mechanistic target of rapamycin), a central nutrient-sensing pathway that drives cell growth. Dampening mTOR activity mimics some effects of calorie restriction and activates autophagy, the cell's recycling process. In the NIA Interventions Testing Program, rapamycin extended median and maximum lifespan in mice, even when started late in life. In humans, a small study of a related mTOR inhibitor improved vaccine response in older adults, and the 2025 PEARL trial found low-dose intermittent rapamycin reasonably well tolerated over 48 weeks with modest, mixed effects on secondary measures. No trial has shown it extends human lifespan or healthspan.
What to Expect
Longevity protocols typically use low doses once weekly (commonly 3–6 mg) rather than the daily dosing used in transplant medicine, to limit immunosuppression and metabolic side effects. There is no established timeline for measurable benefit; monitoring labs are usually repeated after the first few months.
Rapamycin Pricing Comparison
Sorted by lowest starting price.
Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.
| Provider | Score | Product | Price/mo | Includes | |
|---|---|---|---|---|---|
| Healthspan | 71 | The Rapamycin Protocol | $64 | ● Consults● Shipping● Labs | Visit |
| Topical Rapamycin (skin / hair) | $115–$140 | ● Consults● Shipping○ Labs | |||
| AgelessRx | 73 | Rapamycin (sirolimus) | $65 | ● Consults● Shipping○ Labs | Visit |
| Fella Health | 66 | Rapamycin | $99 | ● Consults● Shipping○ Labs | Visit |
| Heally | 64 | Rapamycin | $99 | ● Consults● Shipping○ Labs | Visit |
Common Side Effects
- •Mouth ulcers (stomatitis), the most common complaint
- •Elevated cholesterol and triglycerides
- •Elevated blood glucose
- •Acne or skin rash
- •Slower wound healing
- •Fatigue or mild GI upset
Serious Side Effects
- !Increased infection risk from immunosuppression (much greater at transplant doses)
- !Impaired wound healing after surgery or injury
- !Non-infectious pneumonitis (rare)
- !Worsening glucose control or new-onset diabetes
- !Drug interactions with CYP3A4 inhibitors (such as grapefruit, some antifungals and antibiotics) that can sharply raise blood levels
Rapamycin Is Not For
- ✗People with active or recurrent infections
- ✗People with upcoming surgery or unhealed wounds
- ✗Pregnant or breastfeeding women, or those trying to conceive
- ✗People taking strong CYP3A4 inhibitors or other immunosuppressants without specialist oversight
- ✗People with poorly controlled diabetes or severe hyperlipidemia
Rapamycin — Frequently Asked Questions
Is rapamycin approved for longevity?
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No. Sirolimus is FDA-approved for transplant rejection prevention and LAM. Prescribing it for aging is off-label — legal for a licensed clinician, but based on animal data and early human studies rather than proof of benefit in people.
Is low-dose rapamycin safe?
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Small human studies suggest intermittent low doses are generally tolerated, with mouth sores and lipid or glucose changes the most common issues. It is still an immunosuppressant, so infection risk, surgery timing, and drug interactions all need attention. Monitoring labs are part of responsible prescribing.
How much does rapamycin cost through telehealth?
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Generic sirolimus itself is inexpensive at low weekly doses — often roughly $20–80 per month. Most of the cost of a longevity program is the membership, consults, and labs, putting typical all-in pricing around $50–200 per month.
What about metformin for longevity?
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Metformin is another off-label longevity prescription with supportive observational and animal data. The TAME trial was designed to test whether it delays age-related disease in humans, but results are not available. As with rapamycin, it should be treated as a hypothesis, not an established anti-aging treatment.
Medical disclaimer: The information on this page is for educational purposes only and is not medical advice.Rapamycin requires a prescription from a licensed healthcare provider. Side effects, risks, and suitability vary by individual. Always consult your doctor before starting, stopping, or changing any medication. TelehealthMatch is not a healthcare provider.
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