PT-141 (Bremelanotide) Dosage Calculator & Chart
PT-141, or bremelanotide, is the active ingredient in Vyleesi, an FDA-approved injection for low sexual desire in premenopausal women. Compounded PT-141 comes as a powder you mix yourself, so the number of units per dose depends on how much water you add. Enter your vial and your prescribed dose to see exactly what to draw.
= 0.2 mL of a 5 mg/mL solution, delivering 1 mg.
PT-141 dosage chart
Units on a U-100 insulin syringe for a 10 mg vial, by how much bacteriostatic water was added. Use the calculator for any other vial size.
| Water added | Concentration | 0.5 mg | 1 mg | 1.75 mg | 2 mg |
|---|---|---|---|---|---|
| 1 mL | 10 mg/mL | 5 units | 10 units | 17.5 units | 20 units |
| 2 mL | 5 mg/mL | 10 units | 20 units | 35 units | 40 units |
| 3 mL | 3.33 mg/mL | 15 units | 30 units | 52.5 units | 60 units |
The FDA-labeled dose: Vyleesi
| Vyleesi label | |
|---|---|
| Dose | 1.75 mg by autoinjector, under the skin of the abdomen or thigh |
| Timing | At least 45 minutes before anticipated sexual activity |
| Limit | No more than 1 dose per 24 hours; more than 8 per month not recommended |
| Review | Stop after 8 weeks if there's no improvement |
| Approved for | Premenopausal women with acquired, generalized HSDD |
Vyleesi raises blood pressure briefly (by up to about 6 mmHg systolic, peaking 2–4 hours after a dose), which is why it's not for people with uncontrolled hypertension or known cardiovascular disease. It can also reduce the absorption of oral naltrexone.
How to use the calculator
- Enter the mg of PT-141 in your vial (often 10 mg for compounded vials).
- Enter the mL of bacteriostatic water your pharmacy told you to add.
- Enter your prescribed dose in mg. The calculator shows the units to draw.
A 10 mg vial mixed with 2 mL gives 5 mg/mL, where each unit holds 50 mcg. Write the concentration on the vial when you mix it, and recalculate whenever a new vial arrives.
Frequently Asked Questions
What is the standard PT-141 dose?
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The only FDA-approved product, Vyleesi, is a 1.75 mg injection under the skin of the abdomen or thigh, at least 45 minutes before anticipated sexual activity. It's approved for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Compounded doses for other uses are set by the prescriber.
How often can you take PT-141?
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Under the Vyleesi label, no more than one dose in 24 hours, and more than 8 doses a month isn't recommended. The label says to stop after 8 weeks if there's no improvement.
How many units is 1.75 mg of PT-141?
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It depends on how the vial was mixed. A 10 mg vial with 2 mL of bacteriostatic water is 5 mg/mL, so 1.75 mg is 0.35 mL, or 35 units on a U-100 syringe. With 1 mL of water (10 mg/mL) it's 17.5 units.
Does PT-141 work for men?
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It's not FDA-approved for men. Small studies in the 2000s found subcutaneous doses above about 1 mg produced erections in healthy men, and 4–6 mg doses helped some men who hadn't responded well to sildenafil. Development for ED stopped over blood pressure concerns, so any use in men is off-label.
What are the side effects of PT-141?
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In Vyleesi trials, nausea affected 40% of women (vs 1.3% on placebo), flushing about 20%, injection-site reactions 13% and headache 11%. It briefly raises blood pressure, so it shouldn't be used with uncontrolled high blood pressure or heart disease. About 1% developed darkened skin patches, more often with frequent use.
Medical disclaimer: The example dose only shows how the calculator works; it isn't a recommendation. The dosing limits shown come from the Vyleesi prescribing information. Compounded and off-label use must be prescribed and monitored by a clinician, especially if you have high blood pressure or heart disease. Not medical advice.