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Defy Medical vs Enhance.MD: Which Is Better?

Head-to-head comparison of Defy Medical and Enhance.MD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 66.9/100), leading on experience, product range, reputation. Enhance.MD comes out ahead on trust & safety.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD

Score Breakdown

DimensionDefy MedicalEnhance.MD
Overall Score71.9/100 ✓66.9/100
Trust & Safety30%72/10076/100 ✓
Value25%60/10060/100
Experience20%78/100 ✓68/100
Product Range15%78/100 ✓60/100
Reputation10%80/100 ✓65/100

At a Glance

Founded20112019
HeadquartersTampa, FLSan Diego, CA
Publicly tradedNoNo
Treatment categories32
Treatments listed45
Starting price$150/mo$169/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalEnhance.MD
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$169
Microdose Tirzepatide

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Defy Medical vs Enhance.MD — FAQ

Is Defy Medical better than Enhance.MD?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 66.9/100), leading on experience, product range, reputation. Enhance.MD comes out ahead on trust & safety.

Is Defy Medical or Enhance.MD cheaper?

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Defy Medical has the lower starting price (from $150/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Enhance.MD both offer?

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Both platforms treat Weight Loss / GLP-1. Defy Medical covers 3 treatment categories total and Enhance.MD covers 2.

Still deciding?

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