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Defy Medical vs Renew Youth: Which Is Better?

Head-to-head comparison of Defy Medical and Renew Youth based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 61.2/100), leading on trust & safety, value, experience, reputation. Renew Youth comes out ahead on product range.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

Visit Defy Medical
61

Renew Youth is a long-running (since 1999) bioidentical hormone and longevity practice serving men and women through a national network of affiliated physicians, with pricing disclosed only after a phone consultation.

Visit Renew Youth

Score Breakdown

DimensionDefy MedicalRenew Youth
Overall Score71.9/100 ✓61.2/100
Trust & Safety30%72/100 ✓55/100
Value25%60/100 ✓50/100
Experience20%78/100 ✓66/100
Product Range15%78/10080/100 ✓
Reputation10%80/100 ✓70/100

At a Glance

Founded20111999
HeadquartersTampa, FLWisconsin
Publicly tradedNoNo
Treatment categories37
Treatments listed45
Starting price$150/mo—

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalRenew Youth
Hormone Therapy$150–$250
Women's Bioidentical HRT
—
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
—
Sexual Health——

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Renew Youth

+About 27 years in hormone therapy, one of the longest operating histories among brands reviewed
+Full-spectrum hormone care for both sexes, including thyroid, DHEA/pregnenolone, and adrenal support alongside testosterone and estrogen/progesterone
+4.6/5 Trustpilot rating across about 260 reviews, with the company replying to every negative review
−No pricing published anywhere on the site; costs are disclosed only after a phone consultation
−Treatment pages make overstated safety claims (e.g., testosterone "does not cause prostate cancer," therapy should have "no side effects")
−Reviewers report week-long prescription processing on top of shipping time
Read the full Renew Youth review →

Defy Medical vs Renew Youth — FAQ

Is Defy Medical better than Renew Youth?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 61.2/100), leading on trust & safety, value, experience, reputation. Renew Youth comes out ahead on product range.

What do Defy Medical and Renew Youth both offer?

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Both platforms treat Hormone Therapy, Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and Renew Youth covers 7.

Still deciding?

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