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Defy Medical vs Synergy Rx: Which Is Better?

Head-to-head comparison of Defy Medical and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 51.9/100), leading on trust & safety, experience, product range, reputation. Synergy Rx has the lower entry price (from $109/mo vs $150/mo), so the better value depends on which treatment you need.

72

Physician-led telemedicine hormone clinic offering TRT, women's HRT, peptides, GLP-1s, and sexual-health treatments through its own 503B pharmacy.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionDefy MedicalSynergy Rx
Overall Score71.9/100 ✓51.9/100
Trust & Safety30%72/100 ✓48/100
Value25%60/10060/100
Experience20%78/100 ✓50/100
Product Range15%78/100 ✓58/100
Reputation10%80/100 ✓38/100

At a Glance

Founded20112026
HeadquartersTampa, FL—
Publicly tradedNoNo
Treatment categories33
Treatments listed49
Starting price$150/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryDefy MedicalSynergy Rx
Weight Loss / GLP-1$150–$250
GLP-1 Weight Loss (Semaglutide/Tirzepatide)
$199
Compounded Semaglutide (injectable)
Sexual Health—$275
PT-141 (bremelanotide)

Defy Medical

+15 years in operation (founded 2011) — one of the longest-running cash-pay hormone-therapy telehealth brands, with a named Medical Director (Dr. Justin Saya)
+Trustpilot rating of 4.8/5 across 4,144 reviews, and the company responds to 94% of negative reviews, typically within 24 hours
+Broad treatment range from a single provider — TRT, women's HRT, peptides, GLP-1s, sexual dysfunction, and hair loss — dispensed through its own 503B-registered pharmacy with labs required before prescribing
−Pricing is not published on the website; patients must complete a roughly $250 consult before learning treatment costs, a transparency gap versus competitors that post pricing upfront
−Some patients report delays of a week or more between consult and medication fulfillment
−Mobile app quality lags the web experience, per patient feedback
Read the full Defy Medical review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Defy Medical vs Synergy Rx — FAQ

Is Defy Medical better than Synergy Rx?

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Defy Medical scores higher overall in our independent evaluation (71.9/100 vs 51.9/100), leading on trust & safety, experience, product range, reputation. Synergy Rx has the lower entry price (from $109/mo vs $150/mo), so the better value depends on which treatment you need.

Is Defy Medical or Synergy Rx cheaper?

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Synergy Rx has the lower starting price (from $109/mo vs $150/mo for Defy Medical). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Defy Medical and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Sexual Health. Defy Medical covers 3 treatment categories total and Synergy Rx covers 3.

Still deciding?

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