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Enhance.MD vs Josie: Which Is Better?

Head-to-head comparison of Enhance.MD and Josie based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 57.6/100), leading on trust & safety, experience, reputation. Josie comes out ahead on value. Josie has the lower entry price (from $90/mo vs $169/mo), so the better value depends on which treatment you need.

67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

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58
Josie
Fair

Small menopause-focused telehealth brand selling compounded and branded GLP-1s, microdose GLP-1 maintenance plans and estradiol/progesterone HRT at flat published prices.

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Score Breakdown

DimensionEnhance.MDJosie
Overall Score66.9/100 ✓57.6/100
Trust & Safety30%76/100 ✓50/100
Value25%60/10070/100 ✓
Experience20%68/100 ✓58/100
Product Range15%60/10060/100
Reputation10%65/100 ✓45/100

At a Glance

Founded2019—
HeadquartersSan Diego, CA—
Publicly tradedNoNo
Treatment categories23
Treatments listed57
Starting price$169/mo$90/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDJosie
Weight Loss / GLP-1$169
Microdose Tirzepatide
$189
Microdose GLP-1 Maintenance (semaglutide or tirzepatide)

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Josie

+Flat pricing at any dose, published before intake: compounded semaglutide $249/mo ($194/mo prepaid annually), tirzepatide $349/mo ($233/mo annually)
+Offers injectable, oral ODT and microdose ($189/mo) GLP-1 formats alongside HRT in one women's-midlife intake
+Names its lead clinician (Dr. Ana Lisa Carr, MD, board-certified in family medicine) and says it serves all 50 states
−FDA warning letter (Feb 20, 2026) for misbranded compounded semaglutide/tirzepatide marketing
−White-label setup: Josie is a trade name of One Eleven Nutrition LLC on the CareValidate platform, and its terms say it doesn't control provider decisions
−An $80 consultation fee applies if a provider approves a plan and the patient declines medication, and filled orders are non-refundable
Read the full Josie review →

Enhance.MD vs Josie — FAQ

Is Enhance.MD better than Josie?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 57.6/100), leading on trust & safety, experience, reputation. Josie comes out ahead on value. Josie has the lower entry price (from $90/mo vs $169/mo), so the better value depends on which treatment you need.

Is Enhance.MD or Josie cheaper?

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Josie has the lower starting price (from $90/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Josie both offer?

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Both platforms treat Weight Loss / GLP-1. Enhance.MD covers 2 treatment categories total and Josie covers 3.

Still deciding?

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