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Enhance.MD vs Niagen Plus: Which Is Better?

Head-to-head comparison of Enhance.MD and Niagen Plus based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 64.7/100), leading on experience, product range. Niagen Plus comes out ahead on trust & safety, value, reputation. Niagen Plus has the lower entry price (from $149/mo vs $169/mo), so the better value depends on which treatment you need.

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Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

Visit Enhance.MD
65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus

Score Breakdown

DimensionEnhance.MDNiagen Plus
Overall Score66.9/100 ✓64.7/100
Trust & Safety30%76/10078/100 ✓
Value25%60/10070/100 ✓
Experience20%68/100 ✓58/100
Product Range15%60/100 ✓36/100
Reputation10%65/10068/100 ✓

At a Glance

Founded20192024
HeadquartersSan Diego, CALos Angeles, CA
Publicly tradedNoYes (NAGE)
Treatment categories21
Treatments listed51
Starting price$169/mo$149/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDNiagen Plus
Longevity & Peptides$169
NAD+ Therapy
$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

Enhance.MD vs Niagen Plus — FAQ

Is Enhance.MD better than Niagen Plus?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 64.7/100), leading on experience, product range. Niagen Plus comes out ahead on trust & safety, value, reputation. Niagen Plus has the lower entry price (from $149/mo vs $169/mo), so the better value depends on which treatment you need.

Is Enhance.MD or Niagen Plus cheaper?

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Niagen Plus has the lower starting price (from $149/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Niagen Plus both offer?

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Both platforms treat Longevity & Peptides. Enhance.MD covers 2 treatment categories total and Niagen Plus covers 1.

Still deciding?

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