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Enhance.MD vs Synergy Rx: Which Is Better?

Head-to-head comparison of Enhance.MD and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 51.9/100), leading on trust & safety, experience, product range, reputation. Synergy Rx has the lower entry price (from $109/mo vs $169/mo), so the better value depends on which treatment you need.

67

Enhance.MD is a San Diego-based, physician-directed GLP-1 and NAD+ telehealth program that requires baseline and semiannual labs and video visits before and during treatment.

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52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionEnhance.MDSynergy Rx
Overall Score66.9/100 ✓51.9/100
Trust & Safety30%76/100 ✓48/100
Value25%60/10060/100
Experience20%68/100 ✓50/100
Product Range15%60/100 ✓58/100
Reputation10%65/100 ✓38/100

At a Glance

Founded20192026
HeadquartersSan Diego, CA—
Publicly tradedNoNo
Treatment categories23
Treatments listed59
Starting price$169/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryEnhance.MDSynergy Rx
Weight Loss / GLP-1$169
Microdose Tirzepatide
$199
Compounded Semaglutide (injectable)
Longevity & Peptides$169
NAD+ Therapy
$109
B12 Methylcobalamin

Enhance.MD

+Requires baseline labs (CMP, lipids, TSH, HbA1c) before prescribing and repeats them every six months, included in the price
+Named medical director and named fulfilling pharmacies (Tru Meds Rx, Strive, Pharmacy Hub)
+Flat pricing across dose escalation, published before intake, with a full refund if found ineligible
−Billed every 28 days (13 charges a year), making effective annual cost higher than the monthly headline suggests
−Not available in 10 states, including GA, TN and MO
−Trustpilot complaints cite delayed or cancelled shipments and inconsistent results after pharmacy switches
Read the full Enhance.MD review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Enhance.MD vs Synergy Rx — FAQ

Is Enhance.MD better than Synergy Rx?

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Enhance.MD scores higher overall in our independent evaluation (66.9/100 vs 51.9/100), leading on trust & safety, experience, product range, reputation. Synergy Rx has the lower entry price (from $109/mo vs $169/mo), so the better value depends on which treatment you need.

Is Enhance.MD or Synergy Rx cheaper?

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Synergy Rx has the lower starting price (from $109/mo vs $169/mo for Enhance.MD). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Enhance.MD and Synergy Rx both offer?

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Both platforms treat Weight Loss / GLP-1, Longevity & Peptides. Enhance.MD covers 2 treatment categories total and Synergy Rx covers 3.

Still deciding?

Enhance.MD alternativesSynergy Rx alternativesTake the Match Quiz