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Niagen Plus vs Synergy Rx: Which Is Better?

Head-to-head comparison of Niagen Plus and Synergy Rx based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 51.9/100), leading on trust & safety, value, experience, reputation. Synergy Rx comes out ahead on product range. Synergy Rx has the lower entry price (from $109/mo vs $149/mo), so the better value depends on which treatment you need.

65

Prescription-only telehealth program from Nasdaq-listed Niagen Bioscience (formerly ChromaDex) selling an at-home injection kit of nicotinamide riboside (NR), an NAD+ precursor, rather than NAD+ itself.

Visit Niagen Plus
52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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Score Breakdown

DimensionNiagen PlusSynergy Rx
Overall Score64.7/100 ✓51.9/100
Trust & Safety30%78/100 ✓48/100
Value25%70/100 ✓60/100
Experience20%58/100 ✓50/100
Product Range15%36/10058/100 ✓
Reputation10%68/100 ✓38/100

At a Glance

Founded20242026
HeadquartersLos Angeles, CA—
Publicly tradedYes (NAGE)No
Treatment categories13
Treatments listed19
Starting price$149/mo$109/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategoryNiagen PlusSynergy Rx
Longevity & Peptides$149
Niagen At-Home Injection Kit (NR chloride 500 mg, ~28 days)
$109
B12 Methylcobalamin

Niagen Plus

+Backed by a public company with 25+ years of NAD+-precursor research; it holds the patent on the active ingredient (Niagen NRCl)
+Compounded by a 503B outsourcing facility (FDA-registered, cGMP) rather than a patient-specific 503A lab alone
+Flat, published $149 kit price includes the provider consult, a ~28-day supply, supplies and free Next Day Air shipping
−Only one product, and it is NR (an NAD+ precursor), not NAD+; the studies comparing it with NAD+ IV are small and company-sponsored
−The kit showed 'more stock coming soon' at the time of research, so availability is not reliable
−The site does not name the telehealth medical group or the dispensing 503A pharmacy
Read the full Niagen Plus review →

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

Niagen Plus vs Synergy Rx — FAQ

Is Niagen Plus better than Synergy Rx?

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Niagen Plus scores higher overall in our independent evaluation (64.7/100 vs 51.9/100), leading on trust & safety, value, experience, reputation. Synergy Rx comes out ahead on product range. Synergy Rx has the lower entry price (from $109/mo vs $149/mo), so the better value depends on which treatment you need.

Is Niagen Plus or Synergy Rx cheaper?

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Synergy Rx has the lower starting price (from $109/mo vs $149/mo for Niagen Plus). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Niagen Plus and Synergy Rx both offer?

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Both platforms treat Longevity & Peptides. Niagen Plus covers 1 treatment category total and Synergy Rx covers 3.

Still deciding?

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