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Synergy Rx vs TeleDirectMD: Which Is Better?

Head-to-head comparison of Synergy Rx and TeleDirectMD based on our independent scoring across trust, value, experience, product range, and reputation — plus real pricing for the treatments they both offer.

Our Verdict

TeleDirectMD scores higher overall in our independent evaluation (66.5/100 vs 51.9/100), leading on trust & safety, value, experience, reputation. Synergy Rx comes out ahead on product range.

52
Synergy Rx
Below Average

Synergy Rx is a GLP-1 and peptide storefront launched in 2026 on CareValidate's white-label platform. It sells compounded semaglutide and tirzepatide as injections or oral tablets, prescribed through the Lion MD network.

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67

TeleDirectMD is a solo-physician virtual practice offering $79 flat-fee video visits for urgent care, sexual health, skin, women's health and chronic-medication refills in 44 states plus DC.

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Score Breakdown

DimensionSynergy RxTeleDirectMD
Overall Score51.9/10066.5/100 ✓
Trust & Safety30%48/10070/100 ✓
Value25%60/10076/100 ✓
Experience20%50/10066/100 ✓
Product Range15%58/100 ✓54/100
Reputation10%38/10052/100 ✓

At a Glance

Founded2026—
Headquarters——
Publicly tradedNoNo
Treatment categories35
Treatments listed95
Starting price$109/mo$79/mo

Pricing Where They Compete

Prices shown are based on our most recent research and may not reflect current pricing. Telehealth providers update their pricing frequently. Always verify pricing directly with the provider before purchasing.

CategorySynergy RxTeleDirectMD
Sexual Health$275
PT-141 (bremelanotide)
$79
ED Visit

Synergy Rx

+Offers both injectable and oral-tablet compounded semaglutide and tirzepatide
+Names its four dispensing pharmacies and supervising Lion MD physicians
+Wider peptide menu than sibling storefronts: NAD+, sermorelin, glutathione, B12, PT-141
−Independent review found the intake does not screen for medullary thyroid cancer or MEN2 history (GLP-1 boxed-warning contraindication)
−Pricing is withheld until after the consult on the brand's own site; consult fee is disclosed inconsistently ($59 vs $80)
−Launched in 2026 with no Trustpilot, BBB or patient-review history
Read the full Synergy Rx review →

TeleDirectMD

+One all-in $79 cash price per visit, published up front and HSA/FSA eligible
+Every visit is a live video consult with a named, board-certified physician, never a mid-level provider or a questionnaire-only review
+Fast access: visits typically start within 1–2 hours of booking, 7 days a week, and prescriptions go to the patient's own pharmacy
−A single physician handles all visits, which limits capacity and continuity of care
−No GLP-1, weight-loss or controlled-substance prescribing
−Not available in AR, MA, NM, NY, OR or RI
Read the full TeleDirectMD review →

Synergy Rx vs TeleDirectMD — FAQ

Is Synergy Rx better than TeleDirectMD?

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TeleDirectMD scores higher overall in our independent evaluation (66.5/100 vs 51.9/100), leading on trust & safety, value, experience, reputation. Synergy Rx comes out ahead on product range.

Is Synergy Rx or TeleDirectMD cheaper?

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TeleDirectMD has the lower starting price (from $79/mo vs $109/mo for Synergy Rx). Starting prices are for the cheapest treatment each offers — compare the specific treatment you need, and check what each price includes.

What do Synergy Rx and TeleDirectMD both offer?

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Both platforms treat Sexual Health. Synergy Rx covers 3 treatment categories total and TeleDirectMD covers 5.

Still deciding?

Synergy Rx alternativesTeleDirectMD alternativesTake the Match Quiz